Publications by authors named "Andrew Mayfield"
Background: Individuals who gave birth from May 2021 through July 2021 at Atrium Health Wake Forest Baptist (AHWFB) Hospital were surveyed to identify barriers to prenatal care (PNC), assess adequacy of PNC, and examine how these measures relate to race, ethnicity, and income.
Methods: A survey was administered to 200 individuals giving birth at AHWFB. Eligibility included English- or Spanish-speaking, aged 18 years or older, and a gestational age of 35 weeks or greater at delivery.
Article Synopsis
- RIPTACs (Regulated Induced Proximity Targeting Chimeras) are innovative small molecules designed to create stable complexes between a target protein found in tumor cells and a widely expressed essential protein, leading to cancer cell death.
- This approach targets proteins that are specifically expressed in cancer cells without needing them to be the main drivers of the disease, thus offering a new strategy for cancer treatment.
- In the study, RIPTACs were engineered with ligands linked to various effector molecules, demonstrating selective accumulation in target-expressing cells and effectively inducing an anti-proliferative effect.
Objective: Evaluate the effectiveness of text messages to systematically engage parents/guardians ("caregivers") to reschedule a well-child visit (WCV) that was missed ("no-show") and attend that rescheduled WCV visits.
Methods: Patients <18 years in one of five pediatrics or family medicine clinics, in one health system in the Southeast US, were eligible. Patients without a rescheduled WCV after a no-show were randomized into intervention (text messages) or care-as-usual comparison, stratified by language (English/Spanish).
Objective: To solicit information/suggestions from prostate cancer survivors to improve survivorship experiences specific to work/workability.
Design: The study employed a qualitative/phenomenological approach. Black/African-American and white prostate cancer survivors who: (1) had prostatectomy or radiation therapy 6-36 months prior, (2) were working for pay within 30 days before having treatment, and (3) expected to be working for pay 6 months later ( = 45) were eligible for this study.
We report a new method for stereoselective -furanosylation reactions promoted by a precisely tailored bis-thiourea hydrogen-bond-donor catalyst. Furanosyl donors outfitted with an anomeric dialkylphosphate leaving group undergo substitution with high anomeric selectivity, providing access to the challenging 1,2- substitution pattern with a range of alcohol acceptors. A variety of stereochemically distinct, benzyl-protected glycosyl donors were engaged successfully as substrates.
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