Publications by authors named "Andrew Mareczko"
Cancers (Basel)
April 2022
Article Synopsis
- This study analyzed tumor and adjacent normal tissue samples from 165 colorectal carcinoma (CRC) patients to examine changes in relative telomere length (RTL) and its links to various histological and molecular traits.
- It was found that CRC tissues had significantly shorter RTL compared to normal tissues, indicating a shortening equivalent to what is typically observed in the aging process over a decade.
- The research also showed that RTL shortening was consistent across different demographics and tumor characteristics, being notably more pronounced in low-grade CRC and tumors with microsatellite instability (MSI); additionally, it was associated with specific changes in gene expression related to DNA replication and apoptosis.
