A 23-year analysis of litigation in orthopedic elbow surgery.

Background: The reasons for malpractice litigation in elbow surgery are not well understood. The aim of this study is to report the most frequently litigated surgeries of the elbow and analyze the reasons for litigation and case outcomes.

Methods: A retrospective review of the Westlaw legal database was performed, and all federal and state jurisdiction litigation cases involving the elbow from 2000 to 2023 were queried.

Di-berberine conjugates as chemical probes of MexXY-OprM efflux function and inhibition.

The Resistance-Nodulation-Division (RND) efflux pump superfamily is pervasive among Gram-negative pathogens and contributes extensively to clinical antibiotic resistance. The opportunistic pathogen contains 12 RND-type efflux systems, with four contributing to resistance including MexXY-OprM which is uniquely able to export aminoglycosides. At the site of initial substrate recognition, small molecule probes of the inner membrane transporter (e.

A dataset of direct observations of sea ice drift and waves in ice.

Variability in sea ice conditions, combined with strong couplings to the atmosphere and the ocean, lead to a broad range of complex sea ice dynamics. More in-situ measurements are needed to better identify the phenomena and mechanisms that govern sea ice growth, drift, and breakup. To this end, we have gathered a dataset of in-situ observations of sea ice drift and waves in ice.

Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance.

The search for antibiotics that function through novel mechanisms of action is ongoing, and recent progress in our lab identified the tricarboxylic acid cycle as a viable option. Promysalin is a secondary metabolite capable of species-specific inhibition of , a common opportunistic pathogen. Promysalin disrupts primary metabolism in this bacterium by competitively inhibiting succinate dehydrogenase at the ubiquinone binding site.

A reciprocal translocation involving Aspergillus nidulans snxAHrb1/Gbp2 and gyfA uncovers a new regulator of the G2-M transition and reveals a role in transcriptional repression for the setBSet2 histone H3-lysine-36 methyltransferase.

Aspergillus nidulans snxA, an ortholog of Saccharomyces cerevisiae Hrb1/Gbp2 messenger RNA shuttle proteins, is-in contrast to budding yeast-involved in cell cycle regulation, in which snxA1 and snxA2 mutations as well as a snxA deletion specifically suppress the heat sensitivity of mutations in regulators of the CDK1 mitotic induction pathway. snxA mutations are strongly cold sensitive, and at permissive temperature snxA mRNA and protein expression are strongly repressed. Initial attempts to identify the causative snxA mutations revealed no defects in the SNXA protein.

The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2.

The ongoing SARS-CoV-2 pandemic has highlighted the importance of the rapid development of vaccines and antivirals. However, the potential for the emergence of antibiotic resistances due to the increased use of antibacterial cleaning products and therapeutics presents an additional, underreported threat. Most antibacterial cleaners contain simple quaternary ammonium compounds (QACs); however, these compounds are steadily becoming less effective as antibacterial agents.

Tricepyridinium-inspired QACs yield potent antimicrobials and provide insight into QAC resistance.

Quaternary ammonium compounds (QACs) comprise a large class of surfactants, consumer products, and disinfectants. The recently-isolated QAC natural product tricepyridinium bromide displays potent inhibitory activity against S. aureus but due to its unique structure, its mechanism of action remains unclear.

CpG-creating mutations are costly in many human viruses.

Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes.

An Interferometric Synthetic Aperture Radar (InSAR) Habitat Suitability Model to Identify Overwinter Conditions for Coregonine Whitefishes in Arctic Lagoons.

Lagoons provide critical habitats for many fishes, including coregonine whitefishes, which are a mainstay in many subsistence fisheries of rural communities in Arctic Alaska. Despite their importance, little is known about the overwintering habits of whitefishes in Arctic Alaska due to the challenges associated with sampling during winter. We developed a habitat suitability (HS) model to understand the potential range of physical conditions that whitefishes experience during the Arctic winter, using three indicator lagoons that represent a range of environmental characteristics.

Microparticle detection to guide platelet management for the reduction of platelet refractoriness in children - A study proposal.

Microparticles have been shown to shed from a variety of viable cells as a consequence of inflammatory processes, activation or physical stress. Seventy to 90% of circulating microparticles are thought to be platelet-derived. The content of microparticles in blood collected from normal blood donors is highly variable and transfers into the final blood component.

Distal ulna leiomyosarcoma treated with custom polymethylmethacrylate prosthesis with a 4-year follow-up.

Background: Intraosseous leiomyosarcoma is a rare neoplasm having an aggressive biologic behavior. The distal end of the ulna is a very uncommon site for this type of primary bone tumor frequently mistaken for benign lesions. En bloc resection of the distal ulna with reconstruction is a valid option as a limb salvage procedure for the treatment of this difficult problem, minimizing local recurrence while preserving hand function.

Sonographic assessment of the medial ulnar collateral ligament distal ulnar attachment.

Objectives: The purpose of this study was to determine whether the long distal attachment of the medial ulnar collateral ligament (MUCL) can be delineated on sonography.

Methods: We used 12 fresh-frozen cadaveric elbows for this study. We performed sonography of the elbow using a coronal-equivalent long-axis view of the MUCL.

Partial subscapularis release for total shoulder arthroplasty: a biomechanical comparison of two techniques.

Background: Glenohumeral joint exposure during total shoulder arthroplasty (TSA) is obtained by releasing the subscapularis (SSC) with either an osteotomy or a tenotomy. Recently, concerns regarding SSC dysfunction after TSA have been raised. In order to avoid this complication, alternative surgical approaches that release the inferior 50% or 10% of the tendon have been described.

Readmission after shoulder arthroplasty.

Background: Health care payers, including the federal government, increasingly base reimbursement on quality. Payers consider readmission rates after total joint arthroplasty an indicator of quality. The Patient Protection and Affordable Care Act contains provisions that preclude payment of hospital cost associated with joint arthroplasty readmissions occurring within 30 days of discharge.

Complications in total shoulder arthroplasty.

A wider spectrum of complications associated with shoulder arthroplasty is expected because of the substantial increase in the prevalence of this procedure over the past decade. It is helpful to review the management and methods needed to prevent the most common complications associated with shoulder arthroplasty.

Coding practices affect the cost of distal radius fracture care.

The purpose of this study was to determine the impact of an Emergency Medicine Department's billing practices on the total cost of care for distal radius fractures. This study identified patients by International Classification of Diseases, Ninth Revision (ICD-9) billing codes treated by the Department of Orthopaedic Surgery (DOS) and Department of Emergency Medicine (DEM) at the University of Arizona. In every case, the surgical modifier 54 was used.

Quantitative analysis of the medial ulnar collateral ligament ulnar footprint and its relationship to the ulnar sublime tubercle.

Background: The medial ulnar collateral ligament is the major soft tissue restraint to valgus displacement of the elbow. Currently, little has been published regarding the medial ulnar collateral ligament's ulnar footprint.

Hypothesis: The medial ulnar collateral ligament has a long attachment onto the ulna and the anatomy of the footprint is consistent.