Publications by authors named "Andrew MacKinnon"

Background: Shift (Black Dog Institute) is the first mobile health smartphone app created to support the mental health of junior physicians. Junior physicians experience demanding work conditions, leading to high levels of psychological distress and burnout. However, they are often concerned about the potential career impacts of seeking mental health support.

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Objective: To evaluate an online training program for physician supervisors with the aim of promoting a mentally healthy workplace by improving their use of both responsive and preventive mental health support strategies.

Study Design: Cluster randomised, waitlist-controlled trial.

Setting, Participants: Royal Australasian College of Physicians fellows who were supervising at least one resident physician in any of the 31 primary health networks in Australia and 20 district health boards in New Zealand (health network clusters).

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Article Synopsis
  • The study investigated the mental health effects of job loss due to the COVID-19 pandemic among 374 Australians, focusing on factors like depression, anxiety, and suicidality over a six-month period.
  • Results showed a general decrease in depression and anxiety symptoms, indicating that people were able to cope better with their challenges over time, regardless of demographics or exercise habits.
  • High COVID-related stress, low resilience, and low coping self-efficacy were linked to worse mental health initially, but these individuals showed significant improvements, suggesting that social welfare policies may have played a protective role in their recovery.
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Introduction: Previous research has shown that cognitive bias modification of interpretations (CBM-I) may be a promising intervention for anxiety in youth; however, results are mixed. Given the high comorbidity between anxiety and depression in youth, it is surprising that no child studies have targeted biases associated with both. This study aims to evaluate the effectiveness and acceptability of an online CBM-I intervention (Mindmaster) for children with symptom scores of anxiety or depression above a borderline or clinical threshold.

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Background: Anxiety and depressive disorders typically emerge in adolescence and can be chronic and disabling if not identified and treated early. School-based universal mental health screening may identify young people in need of mental health support and facilitate access to treatment. However, few studies have assessed the potential harms of this approach.

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  • The study focuses on the use of Contrast Clearance Analysis (CCA) with MRI in patients with lung cancer and brain metastases to improve the accuracy of distinguishing between treatment effects and tumor progression after stereotactic radiosurgery (SRS).
  • In a retrospective analysis of 62 patients, CCA correctly identified the cause of ambiguous MRI changes in 80.6% of cases and helped maintain consistent diagnoses with follow-up imaging in most patients.
  • The research suggests that CCA is a valuable tool in navigating diagnostic challenges in lung cancer treatment, influencing patient management decisions and improving treatment outcomes.
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Background: The use of electronic informed consent (eIC) in decentralized trials offers a pragmatic approach to enrolling participants across multiple geographic areas.

Methods: Using a randomized, cross-over study design, we conducted a qualitative descriptive evaluation of two eIC approaches-text-only eIC and enhanced eIC-in a mock hypertension Phase III clinical trial. We assessed participant comprehension and acceptability (usability, satisfaction, and eIC preference).

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  • The study focused on improving male health outcomes by enhancing men's engagement in psychotherapy through a program called Men in Mind.
  • The trial involved mental health practitioners from Australia and measured their self-rated competence in engaging male clients before and after completing a self-led online program.
  • Results showed that participants who completed Men in Mind had significantly improved their skills in working with men, which may lead to better health outcomes for male clients, although the study had some limitations in its measurement methods.
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Screening for psychological distress may assist in identifying at-risk adolescents. While several measures of adolescent psychological distress have been used, most have limited or suboptimal psychometric properties. This study aimed to assess the psychometric properties of the Distress Questionnaire-5 (DQ5), a brief measure of psychological distress, in a large community-based sample of adolescents.

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Background: Cerebral palsy (CP) is one of the most common childhood disabilities, impacting many areas of a child's life. Increasingly, quality of life (QOL) measures are used to capture holistic wellbeing of children with CP. However most validated QOL measures for children are based on adult perspective only, with limited focus on child perspective.

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Background: There is increasing evidence that depression can be prevented; however, universal approaches have had limited success. Appropriate targeting of interventions to at-risk populations has been shown to have potential, but how to selectively determine at-risk individuals remains unclear. Workplace stress is a risk factor for depression and a target for intervention, but few interventions exist to prevent depression among workers at risk due to heightened stress.

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Introduction: Seven key inflammatory biomarkers were recently found to be associated with the risk of mortality in a multicenter study of massively transfused patients. The aim of this prospective single-center study was to determine which of these early inflammatory markers could predict 30-d mortality among all critically injured trauma patients.

Methods: Serum samples were collected at 6, 24, and 72 h from 238 consecutive patients admitted to the intensive care unit following traumatic injury.

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Background: The Mental Health Support Scale for Adolescents (MHSSA) is a criterion-referenced measure of adolescents' supportive intentions towards peers with mental health problems, which was developed for use in evaluations of adolescent mental health interventions, such as the teen Mental Health First Aid (tMHFA) program. The present study aimed to examine the validity and reliability of the MHSSA.

Methods: A sample of 3092 school students (Mean ± SD: 15.

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Background: Clinical trials suggest that long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) (fish oil) may reduce depressive symptoms in adults with major depressive disorder. Therefore, n-3 PUFAs may be a potential treatment for depression in youth.

Methods: Participants were 15- to-25 year-old individuals with major depressive disorder who sought care in one of three government-funded mental health services for young people in metropolitan Melbourne, Perth, or Sydney, Australia.

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Introduction: Meta-analytical evidence confirms a range of interventions, including mindfulness, physical activity and sleep hygiene, can reduce psychological distress in university students. However, it is unclear which intervention is most effective. Artificial intelligence (AI)-driven adaptive trials may be an efficient method to determine what works best and for whom.

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Background: Rates of depression are increasing among adolescents. A novel way to reduce depression is by improving sleep. We evaluated whether an app-based intervention for insomnia improved sleep and depression, and whether changes in insomnia mediated changes in depression.

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Article Synopsis
  • The study investigates the combined impact of COVID-19 and the Black Summer bushfires on the mental health of Australian adolescents, highlighting a lack of research on their co-occurrence.
  • Participants (N=5866) completed surveys on their experiences with both disasters, assessing mental health outcomes such as depression, anxiety, and suicidal thoughts.
  • Results showed that personal harm from bushfires was linked to worse mental health outcomes, while COVID-19-related exposure also increased trauma, but there were no significant interactive effects between the two disasters on mental health.
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