Publications by authors named "Andrew M Sorn"
98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors' autologous blood and tonsils and sought to answer key questions about T cell receptor biology previously unanswerable by smaller-scale experiments.
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- This study examines how sex-based differences in immune cell composition and function affect adaptive immune responses in human lymphoid tissues, specifically tonsils.
- It found that female tonsils had more memory B cells and produced stronger antibody responses to influenza, particularly after live-attenuated vaccination, compared to male tonsils.
- Additionally, differences in CD4 T cell profiles were seen in adults, indicating that these variations may help explain why males and females respond differently to vaccines and viral infections.
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site.
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