Publications by authors named "Andrew M Macklin"
Article Synopsis
- Meningiomas are the most common primary brain tumors in adults, typically treated with surgery as no effective medications exist.
- The World Health Organization's grading system and surgical extent do not fully predict the tumor's behavior, highlighting the need for clearer molecular classifications.
- Recent research identified four consensus molecular groups based on genetic and protein analysis, which better predict clinical outcomes and inform treatment options by revealing distinct biological characteristics.
Localization of the interface between the candidate antibody and its antigen target, commonly known as epitope mapping, is a critical component of the development of therapeutic monoclonal antibodies. With the recent availability of commercial automated systems, hydrogen / deuterium eXchange (HDX) is rapidly becoming the tool for mapping epitopes preferred by researchers in both industry and academia. However, this approach has a significant drawback in that it can be confounded by 'allosteric' structural and dynamic changes that result from the interaction, but occur far from the point(s) of contact.
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- - Engineered viral strains like oncolytic viruses (OV) and gene therapy vectors are emerging as promising tools for specifically targeting and destroying cancer cells, showing safety and potential effectiveness in clinical settings.
- - Despite their potential, OV therapy exhibits inconsistent results due to the complex and diverse nature of tumors, highlighting the need for strategies that enhance viral replication within cancer tissues.
- - Researchers are developing new small molecules that significantly boost OV replication in cancer cells (up to 2000-fold) while sparing normal tissue, which could improve treatment for resistant tumors and possibly benefit other viral therapies in the future.