Publications by authors named "Andrew M Cyr"
Article Synopsis
- - Postpartum infections can show vague symptoms, as seen in a patient with recurrent fever after a cesarean delivery complicated by chorioamnionitis, initially treated as septic pelvic thrombophlebitis.
- - Despite outpatient treatment with antipyretics and antibiotics (clindamycin & gentamicin), the patient experienced ongoing fever, leading to a hospital re-evaluation.
- - The actual cause was identified as an infected periuterine hematoma and a subcapsular hepatic abscess, treated successfully through drainage and antibiotics (ertapenem & metronidazole), marking a unique case involving rare anaerobic bacteria.
Article Synopsis
- Poly(ADP)ribosylation inhibitors (PARPis), particularly olaparib, selectively kill cancer cells with homologous recombination (HR) deficiency, while enhancing the anti-tumor activity of tumor-associated macrophages (TAMs) in breast cancer models related to BRCA1.
- Olaparib reprograms TAMs, boosting their cytotoxicity and phagocytic capabilities due to an increase in NAD+, which alters energy production and elevates reactive oxygen species (ROS) levels.
- Combining olaparib with CD47 antibody treatment, which blocks the "don't-eat-me signal" to TAMs, leads to improved anti-tumor effects in BRCA
Rocaglates are a family of natural products isolated from the genus which possess a highly substituted cyclopenta[]benzofuran skeleton and inhibit cap-dependent protein synthesis. Rocaglates are attractive compounds due to their potential for inhibiting tumor cell maintenance by specifically targeting eukaryotic initiation factor 4A (eIF4A) and interfering with recruitment of ribosomes to mRNA. In this paper, we describe an intercepted retro-Nazarov reaction utilizing intramolecular tosyl migration to generate a reactive oxyallyl cation on the rocaglate skeleton.
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