Publications by authors named "Andrew L Cross"

Neutrophil extracellular traps (NETs) are associated with rheumatoid arthritis pathogenesis and severity. Since homeostatic NET-forming neutrophils [NET+Ns] have beneficial roles in defense against pathogens, their distinction from pro-injury [NET+N] subtypes is important, especially if they are to be therapeutically targeted. Having identified circulating, pro-injury DEspR+CD11b+[NET+Ns] in patients with neutrophilic secondary tissue injury, we determined whether DEspR+[NET+Ns] are present in rheumatoid arthritis (RA) flares.

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Objectives: Identifying that dysfunction of the IL-23/17 axis underlies PsA has led to the development of effective targeted therapies such as the IL-17A inhibitor secukinumab. As IL-17A stimulates the secretion of neutrophil chemoattractants, such as CXCL8 (IL-8), we examined the effect of secukinumab on neutrophil function in PsA.

Methods: Nineteen patients with active PsA were treated with secukinumab.

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Article Synopsis
  • Neutrophils are crucial in rheumatoid arthritis (RA) by releasing reactive oxygen species (ROS) and enzymes that damage joints; JAK inhibitors like tofacitinib and baricitinib can modify neutrophil function and improve RA symptoms.
  • Clinical trials show that while JAK inhibitors are effective, they can increase infection rates and lead to temporary low neutrophil counts (neutropenia).
  • This study found differences in energy metabolism between neutrophils from healthy individuals and those with RA, revealing that JAK inhibitors reduce ROS and NET production without compromising the neutrophils' ability to fight off bacteria, potentially helping to prevent joint damage.
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Objectives: Reports on the regulation of neutrophil function by IL-6 are often conflicting. Therapeutic inhibition of IL-6 in RA is associated with occasional neutropenia, but the mechanisms underlying this observation are poorly understood. This study investigated interactions between IL-6, the anti-IL-6 receptor agent tocilizumab (TCZ) and neutrophils in vitro and in vivo.

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