Publications by authors named "Andrew Keel"
Article Synopsis
- Psoriasis (PSO) is a chronic autoimmune disease linked to increased risks of heart problems, and this study investigates inflammatory markers in PSO patients, specifically focusing on oxidized mtDNA (ox-mtDNA).
- * Patients with PSO showed higher levels of ox-mtDNA compared to healthy individuals, and these levels were correlated with inflammation markers and negatively associated with good cholesterol levels.
- * Treatment with anti-IL-17a in PSO patients led to decreases in ox-mtDNA and coronary artery issues over a year, suggesting ox-mtDNA could be an important early indicator of heart disease related to autoimmune activity.
APOA-1 is central to the high-density lipoprotein function of reverse cholesterol transport measured by cholesterol efflux capacity. Psoriasis is a systemic inflammatory disease associated with poor cholesterol efflux capacity and accelerated noncalcified coronary burden (NCB) as measured by coronary computed tomographic angiography. In this study, we characterized the relationship between APOA-1, cholesterol efflux capacity, and progression of NCB over 4 years.
View Article and Find Full Text PDFBackground And Aims: Psoriasis is an immune-mediated inflammatory disease with increased risk of myocardial infarction. Preclinical studies in psoriasis models show an association between chronic inflammation and immune cell proliferation in the spleen and bone marrow (BM). We sought to test the hypothesis that splenic and BM F-fluorodeoxyglucose (F-FDG) uptake is heightened in psoriasis and that higher uptake associates with systemic inflammation and subclinical atherosclerotic disease measures in this cohort.
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- Increased left ventricular (LV) mass is linked to heart failure and is influenced by systemic inflammation; this study specifically looks at the role of subclinical coronary artery disease (CAD) in this relationship in individuals with psoriasis.
- The research involved 189 psoriasis patients without known cardiovascular disease, measuring systemic inflammation via plasma glycoprotein A (GlycA) and LV mass using coronary CT angiography (CCTA); results showed a significant association between both GlycA and noncalcified coronary burden (NCB) with LV mass.
- Findings indicate that systemic inflammation and early CAD (represented by NCB) contribute to increased LV mass independently from traditional cardiovascular risk factors, with about 32% of the GlycA-LV mass
Article Synopsis
- The study aimed to explore the link between abdominal subcutaneous adipose tissue (ASAT) and coronary atherosclerosis in people with psoriasis.
- It involved 232 participants undergoing imaging tests to measure their fat tissue and assess heart disease risk, revealing different correlations between ASAT and inflammation or cholesterol levels based on sex.
- Results showed that in men, higher ASAT was linked to lower coronary atherosclerosis risk, while no significant relationship was found for women, indicating the need for further research on how ASAT interacts with chronic inflammation in different sexes.
Psoriasis is associated with a higher risk of liver diseases. We investigated the impact of hepatic steatosis (European cohort) and hepatic inflammation (United States cohort) on subclinical atherosclerosis. In the European cohort (n = 76 psoriasis participants and 76 controls), nonalcoholic fatty liver disease, assessed by the sonographic hepatorenal index, was more prevalent in psoriasis than in controls (61% vs.
View Article and Find Full Text PDFBackground: Psoriasis is associated with a heightened risk of cardiovascular disease and higher prevalence of metabolic syndrome.
Objective: Investigate the effect of metabolic syndrome and its factors on early coronary artery disease assessed as noncalcified coronary burden by coronary computed tomography angiography in psoriasis.
Methods: This cross-sectional study consisted of 260 participants with psoriasis and coronary computed tomography angiography characterization.
Article Synopsis
- Patients with psoriasis show a link between myocardial infarction and increased coronary burden, as evidenced by studies measuring noncalcified coronary burden (NCB) and biomarkers like serum high-sensitivity troponin-T (hs-cTn-T).
- In a study of 202 middle-aged patients, higher NCB was significantly associated with positive hs-cTn-T results at both baseline and one year later, indicating myocardial injury.
- The findings suggest that elevated NCB correlates with impaired coronary blood flow and emphasize the need for further research on early vascular disease to understand its impact on heart health in psoriasis patients.
BACKGROUNDPsoriasis is a chronic inflammatory skin disease associated with increased obesity, noncalcified coronary artery burden (NCB), and incident myocardial infarction. Here, we sought to assess the relationship among inflammation, visceral adipose tissue (VAT), and NCB. Furthermore, we evaluated whether improvement in VAT would be associated with reduction in NCB over time in psoriasis.
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- Lipid-rich necrotic core (LRNC) is a dangerous type of plaque linked to higher cardiovascular risks, particularly in psoriasis patients, who are already at increased risk for heart issues.
- A study involved 209 psoriasis patients who used a special imaging technique to examine LRNC before and after a year of biologic therapy.
- Results showed that patients on biologic therapy had a significant reduction in LRNC, while those not on therapy showed no significant change, indicating that biologic treatment can positively affect heart health in psoriasis patients.
Background And Aims: Amygdalar 18F-fluorodeoxyglucose (FDG) uptake represents chronic stress-related neural activity and associates with coronary artery disease by coronary computed tomography angiography (CCTA). Allostatic load score is a multidimensional measure related to chronic physiological stress which incorporates cardiovascular, metabolic and inflammatory indices. To better understand the relationship between chronic stress-related neural activity, physiological dysregulation and coronary artery disease, we studied the association between amygdalar FDG uptake, allostatic load score and subclinical non-calcified coronary artery burden (NCB) in psoriasis.
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- * This study used a mouse model and human data to investigate how inflammatory cytokines like IFNγ and TNFα influence the formation of cholesterol crystals in endothelial cells, noting significant changes in lysosomal pH and lipid-related proteins.
- * The findings suggest that these cytokines enhance cholesterol crystal formation, contributing to early atherosclerosis and offering insights into the cardiovascular risks associated with psoriasis.
Article Synopsis
- Psoriasis is linked to an increased risk of coronary artery disease, potentially through elevated levels of soluble LOX-1, a receptor that interacts with oxidized lipoproteins.
- A cohort study at the National Institutes of Health involved 175 psoriasis patients to analyze the relationship between soluble LOX-1 and noncalcified coronary burden over time.
- Results showed that psoriasis patients had higher levels of soluble LOX-1 compared to matched controls, suggesting a potential connection to cardiovascular risk.
Article Synopsis
- Psoriasis patients face a higher risk of heart attacks and increased noncalcified coronary burden, which can be evaluated using coronary computed tomography angiography (CCTA).
- This study utilized machine learning algorithms on data from 263 patients to identify key predictors of noncalcified coronary burden, focusing on variables related to body composition and inflammation.
- The top predictors included factors like body mass index and levels of certain lipoproteins, suggesting that addressing obesity, dyslipidemia, and inflammation is vital in managing psoriasis-related health risks.
Article Synopsis
- Psoriasis is a chronic skin disease linked to cardiovascular issues, and while biologic therapies are beneficial for the skin, their impact on coronary inflammation is not fully understood.
- This study examined the effects of biologic therapy on coronary inflammation in psoriasis patients by using a measurement technique called perivascular fat attenuation index (FAI) during coronary CT angiography.
- Out of 134 patients, those who received biologic treatment showed a significant decrease in FAI compared to the control group, suggesting that biologic therapies may help reduce coronary inflammation in psoriasis patients.
Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.
JACC Basic Transl Sci
February 2019
Article Synopsis
- Psoriasis is an inflammatory skin condition that increases the risk of cardiovascular issues and is a useful model for studying inflammation-related heart disease.
- The study highlights the connection between low-density granulocytes (a type of neutrophil) and platelets, specifically how their interaction is linked to the presence of noncalcified coronary plaques measured by coronary CT angiography.
- Since the presence of noncalcified plaques can lead to serious heart attacks, targeting the interaction between low-density granulocytes and platelets could be important for future clinical treatments.
Article Synopsis
- The study investigates the effects of biologic therapy on coronary plaque in psoriasis patients, particularly focusing on inflammation-driven plaque types associated with an increased risk of myocardial infarction (MI).
- The research involved 290 participants, with 121 biologic treatment-naïve individuals being analyzed over a one-year period, revealing reduced non-calcified plaque burden and necrotic core in those receiving biologics.
- Results showed a notable 6% reduction in non-calcified plaque and a significant difference in plaque progression between biologic and non-biologic treatments, indicating potential cardiovascular benefits from biologic therapy in these patients.