A Bibliometric Review of the Top 100 Most Cited Articles in Hip Preservation, Not Counting Self-Citations.

Purpose: To summarize the characteristics of the top 100 most-cited publications related to hip preservation, not counting self-citation.

Methods: Databases accessible through ISI Web of Science were queried for articles related to hip preservation between 1965 and June 2022. Analysis included citation number, visual network mapping, publication year, geographic distribution, authorship, impact factor, citation density, and institution.

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.

T-cell activation releases inositol 1,4,5-trisphosphate (IP3), inducing cytoplasmic calcium (Ca2+) influx. In turn, inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) phosphorylates IP3 to negatively regulate and thereby tightly control Ca2+ fluxes that are essential for mature T-cell activation and differentiation and protection from cell death. Itpkb pathway inhibition increases intracellular Ca2+, induces apoptosis of activated T cells, and can control T-cell-mediated autoimmunity.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for the augmentation of therapeutic efficacy.