Publications by authors named "Andrew Jajack"

Article Synopsis
  • - The COVID Moonshot was a collaborative, open-science effort focused on finding a new drug to inhibit the SARS-CoV-2 main protease, which is crucial for the virus's survival.
  • - Researchers developed a novel noncovalent, nonpeptidic inhibitor that stands out from existing drugs targeting the same protease, employing advanced techniques like machine learning and high-throughput structural biology.
  • - Over 18,000 compound designs, 490 ligand-bound x-ray structures, and extensive assay data were generated and shared openly, creating a comprehensive and accessible knowledge base for future drug discovery efforts against coronaviruses.
View Article and Find Full Text PDF

Peripheral biochemical monitoring involves the use of wearable devices for minimally invasive or noninvasive measurement of analytes in biofluids such as interstitial fluid, saliva, tears and sweat. The goal in most cases is to obtain measurements that serve as surrogates for circulating analyte concentrations in blood. Key technological developments to date include continuous glucose monitors, which use an indwelling sensor needle to measure glucose in interstitial fluid, and device-integrated sweat stimulation for continuous access to analytes in sweat.

View Article and Find Full Text PDF

Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors).

View Article and Find Full Text PDF

Sweat sensing may provide a noninvasive means of estimating blood biomarker levels if a number of technological hurdles can be overcome. This report describes progress on a physiologically based transport model relating sweat glucose and key electrolyte concentrations to those in blood. Iontophoretically stimulated sweat glucose and fasted blood glucose were simultaneously measured in 2 healthy human subjects.

View Article and Find Full Text PDF

Non-invasive wearable biosensors provide real-time, continuous, and actionable health information. However, difficulties detecting diluted biomarkers in excreted biofluids limit practical applications. Most biomarkers of interest are transported paracellularly into excreted biofluids from biomarker-rich blood and interstitial fluid during normal modulation of cellular tight junctions.

View Article and Find Full Text PDF

Fermentation by fungi converts stored pollen into bee bread that is fed to honey bee larvae, Apis mellifera, so the diversity of fungi in bee bread may be related to its food value. To explore the relationship between fungicide exposure and bee bread fungi, samples of bee bread collected from bee colonies pollinating orchards from 7 locations over 2 years were analyzed for fungicide residues and fungus composition. There were detectable levels of fungicides from regions that were sprayed before bloom.

View Article and Find Full Text PDF

The impact of maggot mass size on body water content, net transpiration rate, and dehydration tolerance of fly pupae was examined in six species of necrophagous flies. Species that spent more time on food as larvae, produced pupae with high body water contents. Dehydration tolerance limits of pupae were modest, matching the moisture-rich conditions of decaying carrion for larvae.

View Article and Find Full Text PDF

To examine how traumatic insemination, a wounding process to females inflicted by males during copulation, reduces the longevity of females of the bedbug, Cimex lectularius, we assessed if multiple bouts of mating impact water relations of females by measuring net transpiration water loss rates. Our studies show that net transpiration rate of females correlates with frequency of mating (small increase after exposure to low numbers of males; large increase after exposure to large numbers of males), and this is reflected by reduced female survivorship for as much as 22 days at 75% RH, 25°C. Water loss occurs up to 28% more rapidly in females after being held with large groups of males.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Andrew Jajack"

  • - Andrew Jajack's recent research primarily focuses on innovative drug discovery methods, as demonstrated in his 2023 article on noncovalent SARS-CoV-2 main protease inhibitors, utilizing an open-science approach that combines crowdsourcing and advanced computational techniques.
  • - In addition to his work on viral inhibitors, Jajack has contributed to advancements in wearable biosensor technology for biochemical monitoring, including the development of models for noninvasive estimation of blood biomarker levels through sweat and other biofluids.
  • - His interdisciplinary studies also explore ecological impacts, such as the effects of fungicide on beneficial fungi in honey bee bread, indicating a broad research scope that addresses health, technology, and environmental issues.