Publications by authors named "Andrew J Tomarken"

Individuals with autism spectrum disorder (ASD) report high levels of co-occurring mood disorders. Previous work suggests that people with ASD also experience aberrant responses to social reward compared to typically developing (TD) peers. In the TD population, aberrant reward processing has been linked to anhedonia (i.

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There is substantial evidence for individual differences in personality and cognitive abilities, but we lack clear intuitions about individual differences in visual abilities. Previous work on this topic has typically compared performance with only 2 categories, each measured with only 1 task. This approach is insufficient for demonstration of domain-general effects.

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Recent reports have shown that individuals from small hometowns show relatively poor face recognition ability as measured by the Cambridge Face Memory Test or CFMT (Balas & Saville, 2015, 2017), suggesting that the number of faces present in an individual's visual environment relates to that individual's face recognition ability. We replicate this finding in a sample from a different region (Nebraska) and with more variable age distribution. We extend the study by using another test of face recognition ability that does not require learning over trials, and with non-face object recognition tests that share the learning format with the CFMT.

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Background: Autism spectrum disorder (ASD) is marked by repetitive thinking and high rates of depression. Understanding the extent to which repetitive negative thinking in ASD reflects autistic stereotypy versus general depressive thinking patterns (e.g.

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Disgust has been implicated in the fear of contamination that is commonly observed in obsessive-compulsive disorder (OCD). However, basic and treatment-oriented research has shown that disgust is resistant to extinction among those with a fear of contamination. Consequently, there is growing interest in discovering novel approaches to targeting heightened disgust responding among those with OCD.

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Binocular rivalry occurs when markedly different inputs to the two eyes initiate alternations in perceptual dominance between the two eyes' views. A link between individual differences in perceptual dynamics of rivalry and concentrations of GABA, a prominent inhibitory neurotransmitter in the brain, has highlighted binocular rivalry as a potential tool to investigate inhibitory processes in the brain. The present experiment investigated whether previously reported fluctuations of GABA concentrations in a healthy menstrual cycle (Epperson et al.

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The current study used a multifaceted approach to assess whether children with ASD have a distinctive diurnal rhythm of cortisol that differentiates them from typically developing (TD) peers and whether sub-groups of ASD children can be identified with unique diurnal profiles. Salivary cortisol was sampled at four time points during the day (waking, 30-min post-waking, afternoon, and evening) across three days in a sample of 36 children with autism spectrum disorder (ASD) and 27 typically developing (TD) peers. Between-group comparisons on both mean levels and featural components of diurnal cortisol indicated elevated evening cortisol and a dampened linear decline across the day in the ASD group.

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WE LIVE IN A CLUTTERED, DYNAMIC VISUAL ENVIRONMENT THAT POSES A CHALLENGE FOR THE VISUAL SYSTEM: for objects, including those that move about, to be perceived, information specifying those objects must be integrated over space and over time. Does a single, omnibus mechanism perform this grouping operation, or does grouping depend on separate processes specialized for different feature aspects of the object? To address this question, we tested a large group of healthy young adults on their abilities to perceive static fragmented figures embedded in noise and to perceive dynamic point-light biological motion figures embedded in dynamic noise. There were indeed substantial individual differences in performance on both tasks, but none of the statistical tests we applied to this data set uncovered a significant correlation between those performance measures.

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Williams syndrome (WS) is a neurodevelopmental genetic disorder associated with high rates of anxiety and social issues. We examined diurnal cortisol, a biomarker of the stress response, in adults with WS in novel and familiar settings, and compared these profiles to typically developing (TD) adults. WS and TD participants had similar profiles in a familiar setting, while participants with WS had elevated cortisol late in the day in the novel setting when social demands were higher.

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The present study examined the extent to which safety behaviors exacerbate symptoms of hypochondriasis (severe health anxiety). Participants were randomized into a safety behavior (n=30) or control condition (n=30). After a baseline period, participants in the safety behavior condition spent one week actively engaging in a clinically representative array of health-related safety behaviors on a daily basis, followed by a second week-long baseline period.

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Although contamination sensitivity has been implicated in several disorders, there is a paucity of research examining the influence of this trait on various outcomes. Accordingly, the present study examined the extent to which individual differences in contamination sensitivity moderated state affect in response to a mood induction and subsequent information processing biases, as assessed by a lexical decision task (LDT). It was hypothesised that the moderating effects of contamination sensitivity would be specific to disgust responding to a negative but not positive mood induction, and to reaction times to disgust and fear compared to happy words on the LDT.

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Affective startle eyeblink modulation by unipolar depressed and nondepressed participants was assessed during the anticipation and viewing of emotional pictures. Anticipatory startle probes were presented at 2,000 ms and 750 ms before picture onset. Startle probes during picture viewing were presented at 300 ms and 3,500-4,500 ms after picture onset.

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Article Synopsis
  • Structural Equation Modeling (SEM) is a widely used technique in clinical research that offers various strengths, particularly with new methods like latent growth modeling and multilevel SEM, which enhance its flexibility.
  • While SEM has many advantages, it also has limitations, such as issues with omitted variables, overemphasis on high-level model fit, and inaccuracies in common guidelines.
  • The review emphasizes the need for proper study design and gives recommendations for conducting SEM analyses and effectively reporting results.
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The Barnes maze is a spatial memory task that requires subjects to learn the position of a hole that can be used to escape the brightly lit, open surface of the maze. Two experiments assessed the relative importance of spatial (extra-maze) versus proximal visible cues in solving the maze. In Experiment 1, four groups of mice were trained either with or without a discrete visible cue marking the location of the escape hole, which was either in a fixed or variable location across trials.

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Background: We assessed the therapeutic effects of venlafaxine XR and paroxetine on mood and anxiety symptoms derived from the tripartite model of mood. We hypothesized that the two antidepressants would have largely similar effects on symptoms of negative affect because both agents influence serotonergic systems. However, based on evidence indicating linkages between catecholaminergic activity and the emotional dimension of positive affect, we hypothesized that the catecholaminergic effects of venlafaxine XR would yield particularly pronounced effects on symptoms of positive affect.

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We tested the prediction that resting frontal brain asymmetry would be a marker of vulnerability for depression among adolescents. Baseline electroencephalographic (EEG) activity was recorded from 12 to 14-year-old adolescents whose mothers had a history of depression (high risk group) and whose mothers were lifetime-free of axis I psychopathology (low risk group). High risk adolescents demonstrated the hypothesized pattern of relative left frontal hypo-activity on alpha-band measures.

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In two experimental sessions, we assessed early- and late-onset acoustic startle eyeblink modulation and subjective ratings of emotional pictures by nondepressed participants and by unipolar depressed participants. Depressed participants were assessed before and after treatment with the antidepressant medication Bupropion SR. Both depressed and nondepressed participants exhibited arousal-dependent startle modulation to early probes occurring 300 ms after picture onset.

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Background: We assessed the therapeutic effects of bupropion SR and placebo on mood and anxiety symptoms derived from the tripartite model of mood. Based on evidence indicating linkages between dopaminergic activity and the emotional dimension of positive affect/anhedonia, we hypothesized that the dopaminergic effects of bupropion SR would yield particularly pronounced effects on symptoms of anhedonia, relative to anxiety.

Methods: Nineteen depressed outpatients were randomly assigned to treatment with either bupropion SR 300 mg/day or placebo during a 6-week initial treatment phase.

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The assessment of model fit is a more complex and indeterminate process than is commonly acknowledged by researchers who use structural equation modeling (SEM) techniques. Even models that are well fitting according to commonly used statistical tests and descriptive fit indices can have significant problems and ambiguities. The authors discuss 7 potential difficulties that can arise and that should temper researchers' conclusions: equivalent models, nonequivalent but well-fitting alternative models, omitted variables, problematic lower-order model components, the failure to parse composite models into meaningful partitions (e.

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Structural equation modeling (SEM) is a frequently used data-analytic technique in psychopathology research. This popularity is due to the unique capabilities and broad applicability of SEM and to recent advances in model and software development. Unfortunately, the popularity and accessibility of SEM is matched by its complexities and ambiguities.

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Although affective modulation of the startle reflex is a highly replicable effect, the majority of studies have administered startle probes during exposure to affective stimuli. To examine more comprehensively the temporal course of startle potentiation, we assessed blink modulation before, during and immediately after exposure to positive, negative and neutral pictures. During each trial, cues about the affective content of pictures were presented, after which acoustic startle probes were delivered either before picture onset, during picture onset or immediately after picture offset.

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