Publications by authors named "Andrew J Cipriano"
Article Synopsis
- ATR kinase plays a vital role in managing DNA damage responses and cell cycle checks, and its inhibitors (ATRi's) enhance CD8 T cell responses when combined with radiation in cancer models.
- ATRi's trigger CDK1-dependent DNA replication processes in CD8 T cells while reducing key enzymes needed for nucleotide production, leading to genomic issues like dU contamination and R loops.
- Thymidine can counteract some of the harmful effects caused by ATRi's, suggesting that controlling dU contamination is crucial for reducing side effects in cancer treatment and improving T cell anti-tumor responses.
