Publications by authors named "Andrew J Alt"
Article Synopsis
- * The study identifies the bradykinin receptor B1 (B1R) as the GPCR responsible for sCD13's effects on arthritis and shows that B1R is highly expressed in the synovial tissue of rheumatoid arthritis patients.
- * Blocking B1R reduced inflammation in various mouse models of arthritis and suggested that targeting B1R could be a promising treatment approach for rheumatoid arthritis and similar inflammatory conditions.
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing selective antagonists for GLUK5-containing kainate receptors. UBP296 was found to be a potent and selective antagonist of native GLUK5-containing kainate receptors in the spinal cord, with activity residing in the S enantiomer (UBP302). In cells expressing human kainate receptor subunits, UBP296 selectively depressed glutamate-induced calcium influx in cells containing GLUK5 in homomeric or heteromeric forms.
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