Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension.

Background/aims: Topical agents to lower intraocular pressure (IOP) are the most common initial therapeutic measure in glaucoma prevention. This study aims to assess treatment success duration among patients initiating or intensifying topical glaucoma medication.

Methods: Medical records (2013‒2018) for adults initiating/intensifying topical glaucoma medication were extracted from five secondary-care and tertiary-care UK ophthalmology centres.

Burden of Glaucoma in the United Kingdom: A Multicenter Analysis of United Kingdom Glaucoma Services.

Objective: To determine the spectrum of glaucoma-associated health care resource utilization among outpatients attending National Health Service (NHS) hospital glaucoma clinics and the costs of managing glaucoma in this setting.

Design: Retrospective observational cohort study using electronic medical record data.

Subjects: Patients aged ≥ 18 years attending 5 NHS glaucoma clinics in the United Kingdom (2013‒2018) with ≥ 12 months of continuous electronic medical record data.

Combining Structural and Vascular Parameters to Discriminate Among Glaucoma Patients, Glaucoma Suspects, and Healthy Subjects.

Purpose: Compare the ability of peripapillary and macular structural parameters, vascular parameters, and their integration to discriminate among glaucoma, suspected glaucoma (GS), and healthy controls (HCs).

Methods: In this study, 196 eyes of 119 patients with glaucoma (n = 81), patients with GS (n = 48), and HCs (n = 67) underwent optical coherence tomography (OCT) and OCT angiography to measure peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell-inner plexiform layer (mGCIPL) thicknesses, radial peripapillary capillary perfusion density (RPC-PD), and macular GCIPL perfusion density (GCIPL-PD). Parameters were integrated regionally with logistic regression and globally with machine learning algorithms.

Forecasting the COVID-19 Epidemic by Integrating Symptom Search Behavior Into Predictive Models: Infoveillance Study.

Background: Previous studies have suggested associations between trends of web searches and COVID-19 traditional metrics. It remains unclear whether models incorporating trends of digital searches lead to better predictions.

Objective: The aim of this study is to investigate the relationship between Google Trends searches of symptoms associated with COVID-19 and confirmed COVID-19 cases and deaths.

Real-World Outcomes of Selective Laser Trabeculoplasty in the United Kingdom.

Purpose: Selective laser trabeculoplasty (SLT) is a common treatment option for managing glaucoma and ocular hypertension. We assessed the real-world effectiveness of SLT and baseline factors associated with treatment success in the United Kingdom.

Design: Retrospective observational study of de-identified electronic medical records (Medisoft Glaucoma module [Medisoft Ltd, Leeds, UK]) from 5 UK ophthalmology teaching centers.

Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial.

Background: Treatments for open-angle glaucoma aim to prevent vision loss through lowering of intraocular pressure, but to our knowledge no placebo-controlled trials have assessed visual function preservation, and the observation periods of previous (unmasked) trials have typically been at least 5 years. We assessed vision preservation in patients given latanoprost compared with those given placebo.

Methods: In this randomised, triple-masked, placebo-controlled trial, we enrolled patients with newly diagnosed open-angle glaucoma at ten UK centres (tertiary referral centres, teaching hospitals, and district general hospitals).

Examining visual field loss in patients in glaucoma clinics during their predicted remaining lifetime.

Purpose: To evaluate the proportion of patients in glaucoma clinics progressing at rates that would result in visual disability within their expected lifetime.

Methods: This retrospective study used visual field (VF) series of at least 3 years' duration from 3790 UK patients in glaucoma clinics calculating rates of loss for each eye using linear regression of mean deviation (MD) over time. Residual life expectancies derived from the UK Office of National Statistics actuarial tables for each patient were combined with these rates to estimate predicted MDs at end of expected lifetime.

Assessment of acute mild hypoxia on retinal oxygen saturation using snapshot retinal oximetry.

Purpose: To study the effect of acute mild hypoxia on retinal oxygen saturation.

Methods: Spectral retinal images were acquired under normoxic and hypoxic conditions for 10 healthy human volunteers (six male, four female, aged 25 ± 5 years [mean ± SD]) using a modified fundus camera fitted with an image-replicating imaging spectrometer (IRIS). Acute, mild hypoxia was induced by changing the oxygen saturation of inhaled air from 21% to 15% using a hypoxia generator with subjects breathing the hypoxic gas mixture for 10 minutes.

Trabeculectomy in the 21st century: a multicenter analysis.

Objective: To evaluate the efficacy and safety of current trabeculectomy surgery in the United Kingdom.

Design: Cross-sectional, multicenter, retrospective follow-up.

Participants: A total of 428 eyes of 395 patients.

Validation of human whole blood oximetry, using a hyperspectral fundus camera with a model eye.

Purpose: To assess the accuracy of human blood oximetry measurements in a model eye with a hyperspectral fundus camera.

Methods: Seven human whole blood samples (two arterial, five venous) were obtained, the oxygen saturations measured with a CO oximeter, and the samples inserted into quartz tubes with internal diameters of 100 and 150 μm. The tubes (n = 20; ten 100 μm and ten 150 μm) were placed within a model eye in front of a background reflectance surface with reflectivities of 20%, 60%, and 99%.

Identification of a retrolental membrane during laser capsulotomy in eyes with a Hydroview intraocular lens.

We report our observation of a distinct membrane on the posterior surface of the Hydroview (Bausch & Lomb Surgical) intraocular lens during laser capsulotomy in 6 patients. In 3 patients, the retrolental membrane was noted during 4 to 6 weeks of follow-up after laser capsulotomy. The technique of a 2-stage laser capsulotomy in this group of patients is described.