Trainees' perspectives and recommendations for catalyzing the next generation of NeuroAI researchers.

At this critical juncture in the development of NeuroAI, we outline challenges and training needs of junior researchers working across AI and neuroscience. We also provide advice and resources to help trainees plan their NeuroAI careers.

Feasibility and tolerability of portable, low-field brain MRI for patients with multiple sclerosis.

Low-field, portable MRI (LF-MRI) promises to expand neuroimaging access for patients with multiple sclerosis (MS). We aimed to measure the feasibility and tolerability of LF-MRI for clinical use in 50 people with MS (mean age 46.5 ± 15.

Disease modifying therapy in the treatment of tumefactive multiple sclerosis: A retrospective cohort study.

Tumefactive multiple sclerosis (TMS) is characterized by large demyelinating brain lesions. This was a retrospective cohort study of 67 patients with TMS between January 2015-2023, examining different disease modifying therapy impact on expanded disability scale score change at follow-up. Median age was 36 with a female predominance.

E = mc : Education (E), medication (m), and conditional cash (c ) to improve uptake of antiseizure medications in a low-resource population: Protocol for randomized trial.

Objective: Most people with epilepsy (PWE) could live seizure-free if treated with one or more antiseizure medications (ASMs). The World Health Organization (WHO) estimates that 75% of PWE in low-resource settings lack adequate antiseizure treatment. Limited education surrounding epilepsy and the out-of-pocket costs of ASMs in particular pose barriers to managing epilepsy in resource-poor, low-income settings.

Impact of a free medication intervention on seizure recurrence and anxious and depressive symptoms in people living with epilepsy in the Republic of Guinea.

Background And Objective: Of ~5 million people living with epilepsy (PLWE) in Sub-Saharan Africa, roughly one-third experience depression and over one third experience anxiety. In Guinea, these issues may be compounded by fewer available resources, such as appropriate anti-seizure medications (ASMs). We aim to quantify seizure frequency, anxiety and depression in PLWE in Guinea, before and after a free ASM intervention and neurologist's consultation.

Improvement in health perception but not quality of life with an antiseizure medication intervention in people with epilepsy in Guinea: A cohort study.

Background: This study assesses perceptions of quality of life (QOL) and overall health in people with epilepsy (PWE) in Guinea after a clinical intervention providing modified and new antiseizure medicine (ASM) regimens.

Methods: Participants 12 years and older diagnosed with active epilepsy were prospectively and consecutively enrolled at two health centers in the Republic of Guinea (one urban, one rural) in 2022. 95% of participants were prescribed new/increased ASM doses, and interviewed for QOL and overall health perceptions at enrollment and three- and six-month follow ups.

High-Density (HD) Scalp EEG Findings in "Benign" Childhood Epilepsy with Centrotemporal Spikes (BCECTS).

Despite characteristic clinical and scalp EEG findings, BCECTS pathophysiology is unclear regarding involvement of large-scale neuronal networks. Higher number of scalp electrodes with HD-EEG may promote accurate localization of the cortical generators in BCECTS providing additional insight in those with neurocognitive problems. We aimed to determine the value of visual interpretation of topographical maps using 256 channels (when compared to standard 21 channel array) HD-EEG in BCECTS and attempted to source localize interictal discharges (IEDs) using Geosource 2 software.

Electronic pill bottles to monitor and promote medication adherence for people with multiple sclerosis: A randomized, virtual clinical trial.

Objective: We perform a randomized trial to test the impact of electronic pill bottles with audiovisual reminders on oral disease modifying therapy (DMT) adherence in people with MS (PwMS).

Methods: Adults with multiple sclerosis (MS) taking an oral DMT were randomized 1:1 for 90 days to remote smartphone app- and pill bottle-based (a) adherence monitoring, or (b) adherence monitoring with audiovisual medication reminders. Optimal adherence was defined as the proportion of doses taken ±3 h of the scheduled time.

Missed opportunities for epilepsy surgery referrals in Bhutan: A cohort study.

Objective: To quantify the missed opportunities for epilepsy surgery referral and operationalize the Canadian Appropriateness of Epilepsy Surgery (CASES) tool for use in a lower income country without neurologists.

Methods: People with epilepsy were recruited from the Jigme Dorji Wangchuck National Referral Hospital from 2014-2016. Each participant was clinically evaluated, underwent at least one standard EEG, and was invited to undergo a free 1.

The Identification of Torsades de Pointes via CEEG: A Case Report on a Patient with Physiologically Provoked Nonepileptic Events.

Continuous electroencephalography (CEEG) is chiefly performed at The Medical University of South Carolina (MUSC) for identifying seizures, including its refined use within the epilepsy monitoring unit (EMU) as a differentiator between epileptic and psychogenic etiologies. CEEG also provides critical data that carry implications outside the bounds of both epilepsy and psychogenic events, such as the characterization of unorthodox clinical phenomena that are of physiological (though nonepileptic) origins. Although nonepileptic events (NEEs) are primarily linked with psychogenic phenomena (conversion disorder, malingering) that can mimic epileptic activity, they, like seizures, have diverse semiologies and etiologies.

Uncovering the Fundamentals of Polarity within the EEG: A Closer Look.

A thorough understanding of the governing concepts of polarity behavior within electroencephalograph (EEG) promotes analytical and thus technical proficiency of the technologist by providing a skill set to logically resolve the myriad of waveform presentations that are expected across all montage derivations. In addition to avoiding a reliance on cursory conceptualization techniques, a solid grasp of the underlying theory of EEG polarity permits a fundamental realization of the cause-effect relationships between the various directions of eye movement and the resulting multitude of wave deflection presentations observed across all montages. Such wisdom can logically account for the futility of using a particular bipolar montage to localize discharges of interest that are located at end-of-chain.

Dimensional Analysis: An Alternative Method for Converting between Interrelated Units of both Timebase and Sensitivity in EEG.

Neurodiagnostics professionals expected to perform EEG calculations involving timebase and sensitivity may benefit from an additional method in which to solve for the answers. Dimensional analysis (DA) is an efficient, organized method that generates answers in a consolidated context. Its coherent, streamlined mechanism allows for efficient computations involving sets of values with diametric units.

Infection rates with use of intra-articular pain catheters in total knee arthroplasty.

Background: Intra-articular pain catheters effectively reduce postoperative pain in total knee arthroplasty (TKA) by delivering analgesia to the surgical site. However, concerns exist regarding the potential for increasing deep infections. This study tested the hypothesis that intra-articular pain catheters in TKA increase the rate of deep surgical site infections.