Publications by authors named "Andrew H Crow"
Chem Biol Drug Des
June 2024
Article Synopsis
- Staphylococcus aureus can invade bone structures and cause infections like osteomyelitis, with the cell wall protein PBP4 being vital for this process.
- Deleting the pbp4 gene prevents the bacteria from invading bone networks and causing disease in mice.
- Research has identified a chemical, phenyl-urea 1, that targets PBP4, and further studies on related compounds have shown potential for better binding and effectiveness against antibiotic resistance.
