A randomized trial of rotavirus vaccine versus sucrose solution for vaccine injection pain.

Objective: Sucrose solutions are analgesic in infants. Oral rotavirus vaccine contains sucrose, however, it is not known if it possesses analgesic properties. The objective was to compare the analgesic effectiveness of rotavirus vaccine to sucrose solution when administered prior to injectable vaccines.

Impact of parent-directed education on parental use of pain treatments during routine infant vaccinations: a cluster randomized trial.

Educating parents about ways to minimize pain during routine infant vaccine injections at the point of care may positively impact on pain management practices. The objective of this cluster randomized trial was to determine the impact of educating parents about pain in outpatient pediatric clinics on their use of pain treatments during routine infant vaccinations. Four hospital-based pediatric clinics were randomized to intervention or control groups.

From the mouth of babes: Getting vaccinated doesn't have to hurt.

Background: Analgesic interventions are not commonly administered during childhood vaccination, despite the fact that two-thirds of children are afraid of needles and one-tenth are noncompliant with immunization.

Objective: To explore children's experiences of vaccination and preferences for analgesia.

Methods: A total of 17 children (four to 14 years of age) at an independent school in Toronto (Ontario) participated in three focus-group interviews.

A randomized controlled trial of clinician-led tactile stimulation to reduce pain during vaccination in infants.

Background: Clinician-led tactile stimulation (rubbing the skin adjacent to the injection site or applying pressure) has been demonstrated to reduce pain in children and adults undergoing vaccination.

Objective: To evaluate the analgesic effectiveness of clinician-led tactile stimulation in infants undergoing vaccination.

Methods: This was a partially blinded randomized controlled trial that included infants undergoing vaccination in a private clinic in Toronto.