Publications by authors named "Andrew Dolson"
Article Synopsis
- The FLO genes in Saccharomyces cerevisiae are regulated by heterochromatin and various cellular factors, with mutations in the POL30 gene affecting gene expression but not specifically the FLO loci.
- Mutations in both POL30 and deletions in replisome stability factors RRM3 and TOF1 led to increased flocculation, showing stronger expression of the FLO11 promoter and altered RNA levels.
- The findings suggest that interactions between POL30, RRM3, and TOF1 are crucial for maintaining epigenetic stability at the FLO11 locus, impacting both active and silent states of gene expression.
Eukaryotic DNA replication is accompanied by the disassembly and reassembly of nucleosomes and the transmission of epigenetic marks to the newly assembled chromatids. Several histone chaperones, including CAF-1 and Asf1p, are central to these processes. On the other hand, replication forks pause at numerous positions throughout the genome, but it is not known if and how this pausing affects the reassembly and maintenance of chromatin structures.
View Article and Find Full Text PDFDbf4-Dependent Kinase (DDK) has a well-established essential role at origins of DNA replication, where it phosphorylates and activates the replicative MCM helicase. It also acts in the response to mutagens and in DNA repair as well as in key steps during meiosis. Recent studies have indicated that, in addition to the MCM helicase, DDK phosphorylates several substrates during the elongation stage of DNA replication or upon replication stress.
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