Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer.

Background: For patients with operable locally advanced esophageal carcinoma (LA-EC), we hypothesized that pre-operative induction chemotherapy followed by chemoradiotherapy (IC-CRT) would improve progression-free survival (PFS) and overall survival (OS) when compared to chemoradiotherapy (CRT).

Methods: This was a single institution retrospective cohort study including patients with LA-EC who received preoperative-intent IC-CRT CRT between 2013-2019. The Kaplan-Meier method was used to estimate OS and PFS.