Publications by authors named "Andrew Dagenais"
Appropriate regulation of the inflammatory response is essential for survival. Interleukin-10 (IL-10), a well-known anti-inflammatory cytokine, plays a major role in controlling inflammation. In addition to immune cells, we previously demonstrated that the IL-10 receptor (IL-10R1) is expressed in dorsal root ganglion sensory neurons.
View Article and Find Full Text PDFPain is closely associated with the immune system, which exhibits sexual dimorphism. For these reasons, neuro-immune interactions are suggested to drive sex differences in pain pathophysiology. However, our understanding of peripheral neuro-immune interactions on sex differences in pain resolution remains limited.
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- Recent research on mice shows that gut microbiota greatly affects bone health, with antibiotic treatment causing an imbalance (dysbiosis) that leads to significant bone loss.
- In experiments, wild-type mice experienced a 31% decrease in bone mass after antibiotic treatment, while lymphocyte-deficient mice did not, indicating that lymphocytes are essential for this bone loss.
- Furthermore, treatment with the bacteria Lactobacillus reuteri post-antibiotics prevented bone loss in wild-type mice, highlighting the potential protective role of certain gut bacteria.
Type-1 diabetes (T1D) increases systemic inflammation, bone loss, and risk for bone fractures. Levels of the anti-inflammatory cytokine interleukin-10 (IL-10) are decreased in T1D, however their role in T1D-induced osteoporosis is unknown. To address this, diabetes was induced in male IL-10 knockout (KO) and wild-type (WT) mice.
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