Publications by authors named "Andrew C Wiechert"
Background: "Financial Toxicity" (FT) is the financial burden imposed on patients due to disease and its treatment. Approximately 50% of gynecologic oncology patients experience FT. This study describes the implementation and outcomes of a novel financial navigation program (FNP) in gynecologic oncology.
View Article and Find Full Text PDFBackground: Ovarian cancer is the leading cause of gynecologic cancer death in the United States despite effective first-line systemic chemotherapy. Cancer stem cells (CSCs) retain the ability to self-renew and proliferate and may be a means of harboring disease that evades standard treatment strategies. We previously performed a high-throughput screen to assess differential protein expression in ovarian CSCs compared to non-CSCs and observed that Thy-1 was more highly expressed in CSCs.
View Article and Find Full Text PDFManagement of a skin metastasis in a patient with advanced ovarian cancer.
Gynecol Oncol Case Rep
December 2013
► Skin metastasis of ovarian cancer is rare, often nodular in appearance, and conveys a poor prognosis. ► This patient developed an unusual maculo-papular rash which was biopsy-proven to be metastatic endometrioid adenocarcinoma. ► Pruritic symptoms from skin metastases should be palliated; SSRIs, local radiation, and topical creams all may play a role.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic pulmonary arterial hypertension (PAH) is a serious condition with unique genetic factors, differentiating it from other types of pulmonary hypertension (PH) such as that caused by idiopathic pulmonary fibrosis (IPF).
- Researchers conducted a comprehensive analysis of lung tissue RNA from 39 subjects, identifying a molecular signature of 4,734 genes that reveal significant biological changes influencing PAH development, including various signaling pathways.
- The study found distinct gene expression patterns in PAH compared to normal subjects and those with PH due to IPF, highlighting the different underlying mechanisms of these conditions, with specific focus on elevated estrogen receptor levels in women with PAH.