PBRM-1/PBAF-regulated genes in a multipotent progenitor in Caenorhabditis elegans.

The Caenorhabditis elegans somatic gonadal precursors (SGPs) are multipotent progenitors that generate all somatic cells of the adult reproductive system. The 2 SGPs originate in the mesodermal layer and are born through a division that produces one SGP and one head mesodermal cell (hmc). One hmc terminally differentiates, and the other dies by programmed cell death.

Primary lymphoma of the breast: A report of two cases.

Primary breast lymphoma (PBL) should be distinguished from secondary breast lymphoma arising in the setting of lymphoma elsewhere in the body. Multimodality imaging is key to diagnosing PBL, and imaging manifestations thereof may indicate PBL and alter the treatment course. Treatment options including chemotherapy, radiation therapy, and/or surgery depend on histology.

Perfusion "brain death" scintigraphy in traumatic and hypoxic cerebral insults: correlation with CT.

In the United States, approximately 1.7 million patients are treated annually for traumatic brain injury, and cerebrovascular insults are the third leading cause of death. Although CT plays a central role in the initial assessment of suspected intracranial injury, planar brain scintigraphy provides valuable information regarding cerebral perfusion, function, and brain death.

Acromioclavicular joint injuries and reconstructions: a review of expected imaging findings and potential complications.

Shoulder injuries, including acromioclavicular (AC) joint separations, remain a common reason for presentation to the emergency room. Although the diagnosis can be made apparent through proper history and physical examination by the emergency medicine physician, ascertaining the degree of injury can be difficult on the basis of clinical evaluation alone. While there is consensus in the literature that low-grade AC joint injuries can be treated with conservative management, high-grade injuries will generally require surgical intervention.

Cancer vaccine development: protein transfer of membrane-anchored cytokines and immunostimulatory molecules.

Many tumor cells escape host-immune recognition by the downregulation or lack of immunostimulatory molecules. Expression of immunostimulatory molecules on tumor cells by gene transfer can be used to induce an antitumor immune response. However, we have previously shown that protein transfer of glycosyl-phosphatidylinositol (GPI)-linked costimulatory molecules is a successful alternative to traditional gene transfer in preparing such a tumor vaccine.