Effect of immediate postoperative intracameral tissue plasminogen activator (tPA) on anterior chamber fibrin formation in dogs undergoing phacoemulsification.

Objective: To evaluate the postoperative effect of intracameral tPA (alteplase; Activase®, Genentech, San Francisco, CA), administered at immediate conclusion of phacoemulsification, on anterior chamber fibrin formation in dogs.

Procedures: Forty-one dogs (82 eyes) undergoing bilateral phacoemulsification received 25 μg/0.1 mL intracameral tPA in one eye and 0.

The effects of topical aqueous sirolimus on tear production in normal dogs and dogs with refractory dry eye.

Purpose: To evaluate the effect of twice daily aqueous 0.02% sirolimus drops on tear production in normal dogs and dogs with refractory keratoconjunctivitis sicca (KCS).

Methods: Two groups of dogs were studied.

Comparison of topically applied flurbiprofen or bromfenac ophthalmic solution on post-operative ocular hypertension in canine patients following cataract surgery.

Objective: To compare the prevalence and kinetics of ocular hypertension after routine cataract extraction when using a predominately COX-2 inhibitor (bromfenac) versus a predominately COX-1 inhibitor (flurbiprofen) in combination with a topical corticosteroid.

Procedures: Patients undergoing unilateral or bilateral cataract surgery were randomly assigned to receive flurbiprofen or bromfenac at the day of surgery and continued for 6 weeks postoperatively, along with topical neo poly dexamethasone. No systemic nonsteroidal anti-inflammatory medications were administered before or after surgery.

Preoperative findings and visual outcome associated with retinal reattachment surgery in dogs: 217 cases (275 eyes).

Objective: Report the correlation of pre-operative findings with visual outcome in dogs undergoing retinal reattachment surgery for giant retinal tears.

Procedures: Retrospective analysis of dogs that underwent pars plana vitrectomy (PPV) with silicone oil (SiO) tamponade and endolaser retinopexy at one institution. Recorded parameters included signalment, etiology, and duration of retinal detachment, observable retinal tissue architecture, visual reflexes, lens status, presurgical aqueous flare, visual status postoperatively, and complications.

Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca.

Objective: To investigate the effect of 0.02% tacrolimus in aqueous suspension on tear production in dogs with keratoconjunctivitis sicca (KCS). Animals studied One hundred five dogs diagnosed with KCS [Schirmer tear test (STT) < or = 10 mm/min and clinical signs of dry eye].