Publications by authors named "Andrew B Wilson"
Article Synopsis
- Researchers analyzed genetic data from 24,202 critically ill COVID-19 cases, showing that host genetics can help identify effective immunomodulatory therapies.
- They conducted a meta-analysis that revealed 49 significant genetic associations, including 16 new ones not previously reported.
- Key findings include potential drug targets related to inflammation, immune response, and viral entry, which could lead to new treatment strategies for severe COVID-19 cases.
Article Synopsis
- Critical COVID-19 is linked to immune system damage in the lungs, showing that genetics play a key role in severe cases requiring hospitalization.
- The GenOMICC study analyzes the genomes of 7,491 critically ill patients against 48,400 controls, uncovering 23 genetic variants that increase the risk for severe COVID-19, including new associations related to immune response and blood type.
- The findings suggest that both viral replication and heightened lung inflammation contribute to critically ill cases, highlighting potential genetic targets for new treatments.
De novo mutations (DNMs), or mutations that appear in an individual despite not being seen in their parents, are an important source of genetic variation whose impact is relevant to studies of human evolution, genetics, and disease. Utilizing high-coverage whole-genome sequencing data as part of the Trans-Omics for Precision Medicine (TOPMed) Program, we called 93,325 single-nucleotide DNMs across 1,465 trios from an array of diverse human populations, and used them to directly estimate and analyze DNM counts, rates, and spectra. We find a significant positive correlation between local recombination rate and local DNM rate, and that DNM rate explains a substantial portion (8.
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