Publications by authors named "Andrew Agnew"
Objective Quantification of Opioid Usage After Thyroid Surgery.
Int Arch Otorhinolaryngol
October 2020
Article Synopsis
- America faces an opioid crisis, with 46 daily overdose deaths from prescription opioids, highlighting a need for reduced opioid use post-surgery.
- A study assessed the actual opioid consumption after thyroid surgery, providing patients with a standard prescription and tracking their usage and pain levels.
- Results showed that 85% of patients used less than 75.0 morphine milligram equivalents (MME), suggesting that alternative anesthesia methods could significantly lessen or eliminate the need for opioid prescriptions after surgery.
Background And Purpose: Obestatin is a recently discovered gastrointestinal peptide with established metabolic actions, which is linked to diabetes and may exert cardiovascular benefits. Here we aimed to investigate the specific effects of obestatin on vascular relaxation.
Experimental Approach: Cumulative relaxation responses to obestatin peptides were assessed in rat isolated aorta and mesenteric artery (n≥ 8) in the presence and absence of selective inhibitors.
N-Acetylgalactosamine kinase (GALK2) is a small molecule kinase from the GHMP family which phosphorylates N-acetylgalactosamine at the expense of ATP. Recombinant GALK2 expressed in, and purified from, Escherichia coli was shown to be active with the following kinetic parameters: Michaelis constant for ATP, 14 +/- 3 microM; Michaelis constant for N-acetylgalactosamine, 40 +/- 14 microM; and turnover number, 1.0 +/- 0.
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