Publications by authors named "Andressa Rocha de Oliveira Sousa"
Structural characterization of a galectin from the marine sponge Aplysina lactuca (ALL) with synergistic effects when associated with antibiotics against bacteria.
Biochimie
November 2023
Lectins presents the ability to interact with glycans and trigger varied responses, including the inhibition of the development of various pathogens. Structural studies of these proteins are essential to better understand their functions. In marine sponges, so far only a few lectins have their primary structures completely determined.
View Article and Find Full Text PDFFibrinogen-related proteins (FREPs) have been identified in several animals. They are involved in the body's defense, acting as mediators of phagocytosis. Ficolins and intelectins are some of the most studied Fibrinogen-related Domain (FReD)-containing lectins.
View Article and Find Full Text PDFStructural characterization of a galectin isolated from the marine sponge Chondrilla caribensis with leishmanicidal potential.
Biochim Biophys Acta Gen Subj
December 2021
Article Synopsis
- * Molecular docking analysis indicated that CCL interacts with carbohydrates in a way similar to other galectins, and it demonstrated significant anti-leishmanial activity by inhibiting the growth of the Leishmania infantum parasite.
- * CCL is recognized as one of the few sponge lectins with a fully determined primary structure, showing great potential for biotechnological applications, particularly in the fight against diseases like Leishmaniasis.
A new lectin from the marine sponge Chondrilla caribensis (CCL) was isolated by affinity chromatography in Sepharose 6B media. CCL is a homotetrameric protein formed by subunits of 15,445 ±2Da. The lectin showed affinity for disaccharides containing galactose and mucin.
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