Diverse perspectives on supporting the health and wellness of people with intellectual and developmental disabilities.

Background: Persons with intellectual and/or developmental disabilities (IDD) are a growing population, frequently living with complex health conditions and unmet healthcare needs. Traditional clinical practice and research methods and measures may require adaptation to reflect their preferences.

Objective: The perspectives of people with IDD, caregivers/partners, and clinicians were obtained to provide insight into factors contributing to the health and wellness of people with IDD.

She Asked for It? Descriptions of Victims' Behaviors Are Associated With Sentencing in Norwegian Rape Trials.

Feminist theorists have long argued that rape myths contribute to normalizing sexual assault, through belittling and denying rape victims' claims. This study examines whether descriptions of victims' behaviors are associated with sentencing in rape trials. A total of 2054 Norwegian court decisions from 2013 to 2023 in judicial records were screened.

Advancing Health Policy and Outcomes for People With Intellectual or Developmental Disabilities: A Community-Led Agenda.

Importance: At least 10 million people in the United States have an intellectual and/or developmental disability (IDD). People with IDD experience considerably higher rates of poor overall health, chronic conditions including diabetes, mental health challenges, maternal mortality, and preventable deaths. This Special Communication proposes national goals based on a community-led consensus model that advances priority health outcomes for people with IDD and their caregivers/partners and identifies critical policy opportunities and challenges in achieving these goals.

Hypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections.

Autonomic dysregulation, including sympathetic hyperactivity, is a common feature of hypertension (HT) and other cardiovascular diseases. The CNS plays a role in driving chronic sympathetic activation in disease, but several lines of evidence suggest that neuroplasticity in the periphery may also contribute. The potential contribution of postganglionic sympathetic neurons to sustained sympathetic hyperactivity is not well understood.

Sustainable Calcite Scale Inhibitors via Oxidation of Lignosulfonates.

Deposition of inorganic scales in wells, flow lines, and equipment is a major problem in the water treatment, geothermal, or upstream oil and gas industries. Deployment of scale inhibitors has been adopted worldwide for oilfield scale prevention. Commercial synthetic scale inhibitors such as polymeric carboxylates and sulfonates or nonpolymeric phosphonates offer good scale inhibition performance but often suffer from one or more limitations including biodegradability, calcium compatibility, and thermal stability.

Transient intracranial pressure elevations (B waves) are associated with sleep apnea.

Background: Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used to define pathological conditions and determine indications for ICP-reducing treatment. We recently showed that nocturnal transient ICP elevations are present in patients without structural brain lesions or hydrocephalus in whom they are associated with sleep apnea. However, whether this signifies a general association between ICP macropatterns and sleep apnea remains unknown.

Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study.

Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia.

"A laugh a day keeps the failure away": The role of self-enhancing humor and host country community embeddedness in career satisfaction of dual-earner expatriate couples.

For dual-earner expatriate couples (DEECs), it is particularly challenging to achieve career satisfaction after relocating to another country and the associated career transitions. While studies have addressed the strenuous career pathways of individuals in DEECs, the identification and empirical analysis of resources that may contribute to the attainment of career satisfaction remains a desideratum. This research investigates the impact of self-enhancing humor and community embeddedness on individual career satisfaction and the crossover effects of humor on that of the partners in DEECs.

Violent assault geographies in northeastern Australia.

As climate change produces more extreme weather, it is increasingly important to understand the impacts of these changes on social behaviour. The relationship between weather and crime has been studied across numerous contexts. However, few studies examine the correlation between weather and violence in southern, non-temperate climates.

Cholinergic collaterals arising from noradrenergic sympathetic neurons in mice.

The sympathetic nervous system vitally regulates autonomic functions, including cardiac activity. Postganglionic neurons of the sympathetic chain ganglia relay signals from the central nervous system to autonomic peripheral targets. Disrupting this flow of information often dysregulates organ function and leads to poor health outcomes.

Modus Operandi in Sexual Assaults of Female Strangers Does Not Change Over Time.

Criminological theories and widespread assumptions about crime suggest that the modus operandi involved in sexual crimes should have changed over time given various contextual changes, such as better criminological knowledge (e.g., forensic awareness) as well as improved investigative techniques (e.

Clinical reasoning of occupational therapists in selecting activities together with older adults with dementia to postpone further development of cognitive decline.

Background: Research suggests that participation in activities has the potential to prevent or delay the development of later-life cognitive decline and dementia. This area is unexplored within occupational therapy.

Aim: To explore and describe the clinical reasoning of occupational therapists in selecting activities together with older adults with dementia to participate in, with the goal to postpone further development of cognitive decline in a sample from the German part of Switzerland.

[Severe metabolic disorder associated with an enterovesical fistula. Report of one case].

Enterovesical fistula (EVF) is a fistulous communication between the intestine and the bladder. It is uncommon and its classic clinical manifestations are the presence of pneumaturia, fecaluria, suprapubic pain and recurrent urinary infections. Surgical repair of EVF leads to rapid correction of both diarrhea and metabolic abnormalities.

Relevance of Deployment Experience and Clinical Practice Characteristics on Military Critical Care Air Transport Team Readiness: A Study of Simulation Construct Validity.

Introduction: The Critical Care Air Transport Team (CCATT) Advanced course utilizes fully immersive high-fidelity simulations to train CCATT personnel and assess their readiness for deployment. This study aims to (1) determine whether these simulations correctly discriminate between students with previous deployment experience ("experienced") and no deployment experience ("novices") and (2) examine the effects of students' clinical practice environment on their performance during training simulations.

Materials And Methods: Critical Care Air Transport Team Advanced student survey data and course status (pass/no pass) between March 2006 and April 2020 were analyzed.

Dementia-friendliness - Inclusion or exclusion: A critical discourse analysis.

This article explores how individuals with dementia and their relatives discursively construct dementia-friendliness in a situation where different definitions of this term exists. Thirteen semi-structured interviews were conducted, including seven individual interviews with people living with dementia. The remaining six interviews consisted of three interviews with the relatives of a person with dementia and three with married couples of which one were diagnosed with dementia.

[Risk factors for adverse drug reactions in patients admitted to intensive care units].

Background: Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR).

Aim: To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU.

Patients And Methods: An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR.

Untangling Peripheral Sympathetic Neurocircuits.

The sympathetic nervous system plays a critical role in regulating many autonomic functions, including cardiac rhythm. The postganglionic neurons in the sympathetic chain ganglia are essential components that relay sympathetic signals to target tissues and disruption of their activity leads to poor health outcomes. Despite this importance, the neurocircuitry within sympathetic ganglia is poorly understood.

k-Shape clustering for extracting macro-patterns in intracranial pressure signals.

Background: Intracranial pressure (ICP) monitoring is a core component of neurosurgical diagnostics. With the introduction of telemetric monitoring devices in the last years, ICP monitoring has become feasible in a broader clinical setting including monitoring during full mobilization and at home, where a greater diversity of ICP waveforms are present. The need for identification of these variations, the so-called macro-patterns lasting seconds to minutes-emerges as a potential tool for better understanding the physiological underpinnings of patient symptoms.

In a world called catastrophe: the impact of COVID-19 on neighbourhood level crime in Vancouver, Canada.

Objectives: To test for statistically significant change in crime rates across neighbourhoods in Vancouver, Canada, resulting from social restrictions within the natural experiment of the COVID-19 pandemic.

Methods: Differential local Moran's is used to identify statistically significant change in crime patterns across Vancouver's neighbourhoods because of COVID-19. These changes are analysed with variables from social disorganization theory constructs using ANOVA.

Coagulation Factor V (F5) is an Estrogen-Responsive Gene in Breast Cancer Cells.

Most breast cancers express estrogen receptor (ER) where estrogen signaling plays an important role. Cancer contributes to activation of the coagulation system leading to an imbalance in the hemostatic system, and coagulation factor (F) V, which is a key regulator of blood coagulation, has been shown to be increased in breast tumors. Thus, the molecular association between estrogens and FV was explored.

Dementia-friendliness - A matter of knowledge, responsibility, dignity, and illusion.

Worldwide, dementia-friendly initiatives are being developed primarily based on and driven by political strategies. Health professionals, local government officials, and initiators alike are working to create dementia-friendly communities, but little is known about how professionals discursively construct dementia-friendliness and how their various interpretations affect current practices in the field. This study aimed to explore how those involved in establishing dementia-friendly initiatives, nursing homes, and dementia villages ascribe meaning to and construct dementia-friendliness.

Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways.

Vagus nerve stimulation (VNS) treats patients with drug-resistant epilepsy, depression and heart failure, but the mechanisms responsible are uncertain. The mild stimulus intensities used in chronic VNS suggest activation of myelinated primary visceral afferents projecting to the nucleus of the solitary tract (NTS). Here, we monitored the activity of second and higher order NTS neurons in response to peripheral vagal activation using therapeutic VNS criteria.

[Neurology and COVID-19: Case Series of Neurological Complications in 96 patients Admitted at a University Hospital].

Background: There are multisystemic consequences secondary to SARS- CoV-2 infection.

Aim: To characterize neurological complications in patients admitted due to SARS-CoV-2 infection.

Methods: Review of medical records of patients aged over 15 years with COVID-19 evaluated by the neurology team between April and August 2020 at a university hospital.

Dedicated C-fiber vagal sensory afferent pathways to the paraventricular nucleus of the hypothalamus.

The nucleus of the solitary tract (NTS) receives viscerosensory information from the vagus nerve to regulate diverse homeostatic reflex functions. The NTS projects to a wide network of other brain regions, including the paraventricular nucleus of the hypothalamus (PVN). Here we examined the synaptic characteristics of primary afferent pathways to PVN-projecting NTS neurons in rat brainstem slices.