CaCO Nanoparticles Delivering MicroRNA-200c Suppress Oral Squamous Cell Carcinoma.

MicroRNA (miR)-200c suppresses the initiation and progression of oral squamous cell carcinoma (OSCC), the most prevalent head and neck cancer with high recurrence, metastasis, and mortality rates. However, -based gene therapy to inhibit OSCC growth and metastasis has yet to be reported. To develop an miR-based gene therapy to improve the outcomes of OSCC treatment, this study investigates the feasibility of plasmid DNA encoding delivered via non-viral CaCO -based nanoparticles to inhibit OSCC tumor growth.

Plasmid encoding delivered by CaCO-based nanoparticles enhances rat alveolar bone formation.

miRNAs have been shown to improve the restoration of craniofacial bone defects. This work aimed to enhance transfection efficiency and -induced bone formation in alveolar bone defects via plasmid DNA encoding delivery from CaCO nanoparticles. The CaCO/ delivery system was evaluated (microscopy, transfection efficiency, biocompatibility) and -induced alveolar bone formation was assessed via micro-computed tomography and histology.