Publications by authors named "Andres N Fernandez"
Article Synopsis
- - Clathrin-mediated endocytosis relies on a branched actin network that provides the force needed for membrane invagination, with actin capping protein (CP) playing a crucial role in regulating actin filament dynamics.
- - Recent research indicates that CP does not just bind randomly to actin but is instead regulated by specific proteins with CP-interacting (CPI) motifs, though the interplay between these proteins remains unclear.
- - The study demonstrates that two proteins, Aim21 and Bsp1, work together to recruit CP to the actin network, while another protein, twinfilin, manages CP turnover after recruitment, showcasing a coordinated approach to regulating CP in endocytosis.
Mol Biol Cell
August 2021
Article Synopsis
- Clathrin- and actin-mediated endocytosis is crucial for eukaryotic cells, with Tda2 identified as a new dynein light chain that regulates actin assembly during this process through its interaction with Aim21.
- Tda2 acts as a dimerization engine, bringing two Aim21 molecules together, and mutations that weaken this interaction affect actin recruitment and dynamics at endocytic sites.
- Aim21 also contains a motif that interacts with actin capping protein, and disrupting it leads to similar issues seen with Tda2 deletion, highlighting the role of the Tda2-Aim21 complex in regulating actin networks during endocytosis.
