Accuracy of beam theory for estimating bone tissue modulus and yield stress from 3-point bending tests on rat femora.

Mechanical analysis of animal long bones often makes use of beam theory to estimate tissue properties from bending tests. An earlier study (van Lenthe et al., 2008) found that beam theory leads to a considerable underestimation of the Young's modulus of mice femora.

Micro-Finite Element analysis will overestimate the compressive stiffness of fractured cancellous bone.

Recently, micro-Finite Element (micro-FE) analysis based on High Resolution peripheral Quantitative CT (HRpQCT) images was introduced to quantify the state of fracture healing (de Jong et al., 2014). That study suggested that the direct post-fracture stiffness may be overestimated by micro-FE.

Effects of magnetic resonance-guided high-intensity focused ultrasound ablation on bone mechanical properties and modeling.

Background: Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a promising technique for palliative treatment of bone pain. In this study, the effects of MR-HIFU ablation on bone mechanics and modeling were investigated.

Methods: A total of 12 healthy rat femurs were ablated using 10 W for 46 ± 4 s per sonication with 4 sonications for each femur.