Publications by authors named "Andres J Alcaraz Romero"
Background: Serum creatinine and estimated glomerular filtration rate (GFR) are key indicators of kidney function.
Methods: This descriptive, retrospective study included neonatal patients admitted to a tertiary hospital's neonatal intensive care unit from January 2013 to December 2016. Data on kidney function were collected from birth to 7 days of life.
Whole Exome Sequencing and Panel-Based Analysis in 176 Spanish Children with Neurodevelopmental Disorders: Focus on Autism Spectrum Disorder and/or Intellectual Disability/Global Developmental Delay.
Genes (Basel)
October 2024
Article Synopsis
- Neurodevelopmental disorders (NDDs) pose significant diagnostic challenges in pediatric genetics, necessitating advanced tools like whole exome sequencing (WES) to identify genetic variants in affected children.
- A study of 176 Spanish-speaking pediatric patients found that the overall diagnostic yield for WES was 17.1%, with varying yields based on specific disorders: 20.8% for intellectual disability (ID), 12.7% for ASD + ID, and 3.2% for autism spectrum disorder (ASD) alone.
- The study supports a sequential diagnostic approach using WES followed by parental testing to enhance accuracy and cost-effectiveness, especially for children with syndromic ID.
Association of Fluid Overload With Clinical Outcomes in Critically Ill Children With Bronchiolitis: Bronquiolitis en la Unidad de Cuidados Intensivos Pediátricos (BRUCIP) Study.
Pediatr Crit Care Med
March 2019
Objectives: Increasing evidence supports the association of fluid overload with adverse outcomes in different diseases. To our knowledge, few studies have examined the impact of fluid balance on clinical outcome in severe bronchiolitis. Our aim was to determine whether fluid overload was associated with adverse clinical outcomes in critically ill children with severe bronchiolitis.
View Article and Find Full Text PDFUnlabelled: Arterial ischemic strokes (AIS) are rare in childhood. Congenital and acquired heart diseases are one of the most important risk factors of AIS in children.
Objective: Study the outcome of children with heart disease that have suffered AIS and the factors that influence on prognosis.
. To determine the epidemiology and therapeutic management of patients with severe acute bronchiolitis (AB) admitted to paediatric intensive care units (PICUs) in Spain. .
View Article and Find Full Text PDFUnlabelled: Valproic acid (VPA) is the most commonly used antiepileptic drug in pediatric patients, but its major drawback is its multiple pharmacological interactions.
Objective: To study children who had been simultaneously treated with carbapenems and valproic acid, considering drug levels, pharmacological interactions and clinical follow-up.
Material And Methods: Retrospective study of children who simultaneously received treatment with VPA and carbapenems between January 2003 and December 2011.
Background: Acute renal injury increases risk of death after cardiac surgery. The objective of the study was to evaluate the ability of the pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease (pRIFLE) criteria to characterize the development of postoperative renal damage in children after cardiopulmonary bypass (CPB) and to evaluate the relationship between the severity of kidney injury and mortality, pediatric intensive care unit (PICU) length of stay, and the duration of mechanical ventilation (MV).
Methods: In this retrospective study including children undergoing CPB surgery during a 3-year period in the PICU of a tertiary hospital, demographic, clinical, surgery-related, and postoperative clinical data were collected.