Publications by authors named "Andres Gonzalez-Delgado"
Article Synopsis
- - Atherosclerotic cardiovascular disease (ACVD) is a serious condition driven by lipid deposits in arteries, leading to inflammation and plaque formation that can cause heart attacks and strokes.
- - The study discovered that a gene deletion causing a lack of factor H-related protein 1 (FHR-1) was protective against ACVD, implying that FHR-1 actually worsens the disease by promoting inflammation.
- - Elevated levels of FHR-1 were found in patients with ACVD and were linked to other inflammation markers and LDL cholesterol, further indicating its role in the disease process.
Oversupply of fatty acids (FAs) to cardiomyocytes (CMs) is associated with increased ceramide content and elevated the risk of lipotoxic cardiomyopathy. Here we investigate the role of ceramide accumulation on mitochondrial function and mitophagy in cardiac lipotoxicity using CMs derived from human induced pluripotent stem cell (hiPSC). Mature CMs derived from hiPSC exposed to the diabetic-like environment or transfected with plasmids overexpressing serine-palmitoyltransferase long chain base subunit 1 (SPTLC1), a subunit of the serine-palmitoyltransferase (SPT) complex, resulted in increased intracellular ceramide levels.
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- - Plasmodium falciparum, the malaria parasite, can bind plasminogen during its development inside red blood cells.
- - This binding helps convert plasminogen into plasmin, which inactivates a component of the immune system called C3b that would otherwise target the parasite.
- - By evading this part of the immune response, the parasite enhances its chances of surviving and thriving in human blood.
Human-induced pluripotent stem cells (h-iPSCs) are a unique in vitro model for cardiovascular research. To realize the potential applications of h-iPSCs-derived cardiomyocytes (CMs) for drug testing or regenerative medicine and disease modeling, characterization of the metabolic features is critical. Here, we show the transcriptional profile during stages of cardiomyogenesis of h-iPSCs-derived CMs.
View Article and Find Full Text PDFCytokines and growth factors are signaling proteins involved in communication processes between cells. They are involved in the control of numerous essential physiological processes such as cell proliferation, gene transcription and differentiation; therefore being in the focus of basic and applied research. Many of them are also of relevance for human diseases.
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