Publications by authors named "Andres G Leon"

Continuing education in hematology is a key for stimulating the development around the world and improving patient outcomes. However, access to training and education is not equally distributed worldwide, and disparities in hematology exist for under-represented groups such as trainees living in low- and middle-income countries (LMICs). To identify and review the different educational and career development opportunities offered by hematology-focused international academic societies directed at healthcare professionals in this field.

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Hematopoietic stem cell transplantation (HSCT) is an effective therapy for acute leukemia (AL). Relapse represents the main cause of mortality. Isolated extramedullary relapse (iEMR) is atypical and has been related to better outcomes.

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Article Synopsis
  • * Between 2009 and 2016, global HSCT use for AML rose significantly, particularly in resource-limited regions, with an overall 54.9% increase, although access remains heavily skewed towards high-resource areas.
  • * Utilization rates vary widely by region, with younger patients (<70 years) experiencing even more disparities; AMR-N showed the highest rates of HSCT, while AFR/EMR and AMR-S lagged far behind.
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Article Synopsis
  • The study analyzed the number of hematopoietic stem cell transplants (HSCTs) performed in Mexico during 2019 and 2020, highlighting the impact of the COVID-19 pandemic on transplant centers (TCs).
  • Nearly 40% fewer HSCTs were conducted in 2020 (505) compared to 2019 (835), with many centers halting operations for an average of 9.9 months during the pandemic.
  • As of 2021, transplant activity is on the rise, approaching pre-pandemic levels, though 9.1% of TCs remained closed, primarily those in the public health system.
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Introduction: Acute myeloid leukemia (AML) is most commonly presented in older adults; however, it appears 10 years earlier in Latin American countries. Clinical evolution in older adults from this populations has not been characterized. We analyzed outcomes and survival predictors.

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Background: Autologous stem cell transplantation (ASCT) is an effective treatment for patients with relapsing myeloma or lymphoma, diseases associated with unsuccessful peripheral blood stem cell (PBSC) collection. Plerixafor is a potent mobilizing agent, allowing more CD34+ cells to be obtained; however, the main obstacle for its use is its high cost. Our aim was to demonstrate that of the use of reduced doses of plerixafor (RD-plerixafor) can be sufficient to collect at least 2 × 10 /Kg CD34+ PBSC in patients with multiple myeloma (MM) or lymphoma undergoing ASCT.

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The presence of cyclodextrins (CDs) in the mobile phase alters the chromatographic equilibria and induces a secondary chemical equilibrium associated to the chromatographic separation by HPLC. In this study the influence of the presence of CDs in the mobile phase as chemically modified beta-CDs, i.e.

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