Publications by authors named "Andres Faria"
Article Synopsis
- The study created 16 new vaccine candidates targeting group A streptococcus (GAS), incorporating a universal T-cell epitope (P25), a GAS-specific B-cell epitope (J14), and a lipid component for better immune response.
- Testing in mice showed that these vaccines triggered specific J14-targeted IgG antibodies after immunization without needing added adjuvants.
- The arrangement of the components significantly impacted the antibody response, with the optimal design placing the lipid moiety at the C-terminus, connected to P25 at the N-terminus and J14 on the lysine side chain.
