Publications by authors named "Andres F Correa-Sanchez"
Chemical conjugation of oligonucleotides is widely used to improve their delivery and therapeutic potential. A variety of strategies are implemented to efficiently modify oligonucleotides with conjugating partners. The linkers typically used for oligonucleotide conjugation have limitations in terms of stability or ease of synthesis, which generates the need for providing new improved linkers for oligonucleotide conjugation.
View Article and Find Full Text PDFArticle Synopsis
- * This disruption leads to the production of faulty transcripts that are targeted for degradation, resulting in reduced UNC13A protein levels and impaired synaptic transmission.
- * Using antisense oligonucleotides to specifically target the problematic splicing changes can restore UNC13A protein levels and improve synaptic function, suggesting a new potential treatment strategy for ALS and related disorders.