Foam sclerotherapy for reticular veins of the chest: a retrospective review of efficacy and safety.

Background: No study has evaluated the use of foam sclerotherapy in treating clinically conspicuous reticular chest veins.

Objective: This retrospective study evaluates patient-rated efficacy, safety, and satisfaction after foam sclerotherapy for reticular veins of the chest.

Materials And Methods: A telephone-based questionnaire was used for patient self-assessment of overall improvement, satisfaction, and adverse events.

Pediatric erythromelalgia: a retrospective review of 32 cases evaluated at Mayo Clinic over a 37-year period.

Background: Erythromelalgia has not been well characterized in the pediatric population.

Objective: We sought to review our experience of erythromelalgia in the pediatric age group.

Methods: We conducted a retrospective review of patients 18 years of age and younger with a diagnosis of erythromelalgia who were examined at Mayo Clinic in Rochester, MN, from 1970 to 2007.

Th17 cells and activated dendritic cells are increased in vitiligo lesions.

Background: Vitiligo is a common skin disorder, characterized by progressive skin de-pigmentation due to the loss of cutaneous melanocytes. The exact cause of melanocyte loss remains unclear, but a large number of observations have pointed to the important role of cellular immunity in vitiligo pathogenesis.

Methodology/principal Findings: In this study, we characterized T cell and inflammation-related dermal dendritic cell (DC) subsets in pigmented non-lesional, leading edge and depigmented lesional vitiligo skin.

Albinism in Africa: stigma, slaughter and awareness campaigns.

Oculocutaneous albinism is an autosomal recessive disorder characterized by a lack of pigment in the hair, skin, and eyes. Albinism is caused by defective or absent tyrosinase, an enzyme necessary for melanogenesis. Although rare in the western world, albinism is quite common in sub-Saharan Africa, likely as a result of consanguinity.

Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction.

Background: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma.

Methods: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn.