Publications by authors named "Andrej Vianin"
Article Synopsis
- Melanoma often spreads to the brain, making it crucial to understand how melanoma cells pass through the blood-brain barrier (BBB) to prevent brain metastases.
- Using primary mouse brain microvascular endothelial cells (pMBMECs), researchers studied how melanoma cells interact with and disrupt the BBB, noting that inhibiting certain proteases can help restore this barrier.
- The study also involved a new melanoma cell line and experiments with PECAM-1-deficient mice, showing that compromised barrier properties lead to increased melanoma cell movement across the BBB, highlighting the importance of maintaining BBB integrity to reduce brain metastasis.
During development, the heart grows by addition of progenitor cells to the poles of the primordial heart tube. In the zebrafish, Wilms tumor 1 transcription factor a (wt1a) and b (wt1b) genes are expressed in the pericardium, at the venous pole of the heart. From this pericardial layer, the proepicardium emerges.
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