Publications by authors named "Andrej Khaitin"
Article Synopsis
- Oxidative stress plays a significant role in various neurological disorders, and photodynamic therapy (PDT) is shown to induce oxidative stress, effectively treating conditions like brain tumors.
- The study examined how different signaling pathways affect neuronal and glial cell responses to PDT in crayfish mechanoreceptors, highlighting the involvement of specific protein kinases in cell death and survival.
- Results indicated that while PDT causes necrosis and apoptosis in neurons and glial cells, certain factors like nitric oxide (NO) and neurotrophic factors (e.g., GDNF, NGF) can offer protective effects against cellular damage from oxidative stress.
The crayfish stretch receptor consisting of the single mechanoreceptor neurons enveloped by satellite glial cells is the simplest functioning neuroglial preparation. However, during isolation, its axons are usually transected that eliminates afferent regulation and induces complex axotomy-related signaling responses in neurons and satellite glia. We developed new microsurgical method of crayfish stretch receptor isolation, which preserves connections of sensory neurons to the ventral nerve cord ganglion.
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