Publications by authors named "Andreina Carbone"

Aims: To assess the presence and the extent of an "aortic remodeling" in elite athletes.

Methods: A systematic review and meta-analysis of literature were conducted for studies (1981-2024) reporting echocardiographic aortic diameters of elite athletes compared to non-athlete healthy controls. Among the 5,494 studies retrieved, 21 (9,464 elite athletes vs.

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Exercise pulmonary hypertension has been invasively defined as mean pulmonary artery pressure/cardiac output slope greater than 3 mm Hg/L/min. Recent advances suggest the sustainable role of exercise Doppler echocardiography for the study of the right heart and pulmonary circulation unit (RH-PCU). Herein, the authors review the invasive versus non-invasive monitoring of the RH-PCU response to exercise in healthy subjects.

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  • SIRS after mitral transcatheter edge-to-edge repair is linked to worse clinical outcomes in patients with severe mitral regurgitation.
  • Forty-four out of 158 patients (27.9%) developed SIRS post-procedure, which was characterized by elevated white blood cell counts and fever.
  • The presence of SIRS significantly increased the risk of major cardiovascular events, including nonfatal heart attacks and deaths, indicating the need for closer monitoring in these patients.
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  • Unicuspid aortic valve (UAV) is a rare heart condition commonly confused with the more common bicuspid aortic valve (BAV), affecting young adults primarily around 36 years old.
  • This study involved a systematic review and meta-analysis of 2953 studies, focusing on the demographic and clinical characteristics of UAV, which often includes associations with conditions like aortic coarctation and Turner syndrome.
  • Surgical intervention, primarily aortic valve replacement (AVR), showed high survival rates (95-98%) over ten years, highlighting the need for further research into UAV as a distinct condition apart from BAV.
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Takotsubo syndrome (TTS) might exhibit particular chronobiological patterns in its onset, characterized by variations according to time of the day, day of the week, and month of the year. The aim of this study was to fully explore the temporal patterns (circadian, weekly and seasonal) in the onset of TTS. A systematic review and meta-analysis of literature were conducted for studies (2006-2024) reporting the temporal patterns (circadian, weekly and/or seasonal) in the onset of TTS.

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  • * Exercise pulmonary hypertension (PH) can be identified through exercise stress echocardiography (ESE) and is significant in predicting symptoms and mortality in HVD patients.
  • * This review seeks to summarize the prognostic importance of exercise PH in valvular diseases and explore its potential integration into the diagnostic and treatment protocols for HVD.*
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: Severe aortic stenosis (AS) is the most frequent valvular heart disease. Models for stratifying cardiac damage associated with aortic stenosis have been developed to predict outcomes following valve replacement. However, evidence regarding morphological and functional evolution, as well as potential changes in the degree of cardiac damage, is limited.

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Introduction: No data are available on the diagnostic algorithms recommended by guidelines for the assessment of diastolic dysfunction (DD) in patients with arterial hypertension.

Aim: To fill this gap, we evaluated diastolic function in hypertensive patients with and without LVH matched with healthy subjects by applying 2016 American Society of Echocardiography-European Association of Cardiovascular Imaging Guidelines for the evaluation of LV diastolic function.

Methods: 717 healthy and hypertensives with normal LV ejection fraction and with and without LV hypertrophy (LVH), matched 1:1:1 from two prospective registries, represented the study population.

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  • Patients may experience Systemic Inflammatory Response Syndrome (SIRS) and related complications after procedures like transcatheter aortic valve implantation and endovascular aortic aneurysm repair due to endothelial disruption and tissue-ischemic response from foreign materials.
  • Symptoms can arise within 0 to 48 hours, and the clinical presentation varies in severity, making diagnosis difficult as it resembles an infection but does not respond to antibiotics.
  • Major complications include prolonged hospital stays, readmissions, and decreased device effectiveness, and treatments involve non-steroidal anti-inflammatory drugs or corticosteroids; further research is needed to understand SIRS mechanisms and improve device compatibility.
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Knowledge about the Health-related Quality of Life (HR-QoL) after Type A (TA-AAD) and Type B acute aortic dissection (TB-AAD) is still insufficient. Through this systematic review, including 22 studies (16 for TA-AAD and 6 TB-AAD -1998-2023), the entire literature on HR-QoL after surgical and/or endovascular and/or medical interventions has been investigated. In TA-AAD patients, despite overall SF-36 score was similar to the standard population, with > 80 years patients displaying a better emotional domain, the SF-12 was significant lower to controls in physical and mental well-being domains.

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Despite guideline recommendations, strategies for implementing cardiac rehabilitation (CR) in patients with acute aortic dissection (AAD) are not well established with little evidence to risk stratify prudent and effective guidelines for the many required variables. We conducted a systematic review of studies (2004-2023) reporting CR following type A (TA) and type B (TB) AAD. Our review is limited to open surgical repair for TA and medical treatment for TB.

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  • The study investigated the safety and effectiveness of oral anticoagulants in octogenarians (80+) with atrial fibrillation, focusing on those with varying kidney function.
  • Data was obtained from a research database, including 901 patients treated with either direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs), analyzing the impact on major bleeding and thromboembolic events.
  • Findings revealed that patients on DOACs had lower mortality rates and fewer complications compared to VKAs, particularly in those with worse kidney function, suggesting DOACs may be a safer option for older patients.
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  • Exercise echocardiography is vital for evaluating the right ventricle and pulmonary circulation, but there's a need for clearer understanding of normal ranges and disease-specific variations.
  • The study involved 2,228 participants including healthy individuals, athletes, and patients with different heart and lung conditions, who underwent echocardiography at rest and during exercise.
  • Key findings indicate that certain measurements can predict increased mortality risk, highlighting significant differences in responses to exercise between healthy subjects and various patient groups.
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At our Pneumology Department, we dealt with three waves of COVID-19 pandemics. The purpose of this study is to compare patients' epidemiological and clinical characteristics across waves and to assess the effect of vaccination on clinical presentation, course, and prognosis. From March 2020 to March 2022, a retrospective cohort study was conducted to compare patient characteristics.

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Obesity is an increasingly widespread disease worldwide because of lifestyle changes. It is associated with an increased risk of cardiovascular disease, primarily type 2 diabetes mellitus, with an increase in major cardiovascular adverse events. Bariatric surgery has been shown to be able to reduce the incidence of obesity-related cardiovascular disease and thus overall mortality.

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Sodium-glucose cotransporter 2 inhibitors (SGLT2-i) are a novel class of oral hypoglycemic agents currently used among patients with type 2 diabetes mellitus (T2DM). The effects of SGLT2-i inhibitors on cardiac structure and function are not fully understood. The aim of this study is to evaluate the echocardiographic changing among patients with well-controlled T2DM treated with SGLT2-i in real-world setting.

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Aim: we sought to test the inter-center reproducibility of 16 echo laboratories involved in the EACVI-Afib Echo Europe.

Methods: This was done on a dedicated setting of 10 patients with sinus rhythm (SR) and 10 with persistent atrial fibrillation (AF), collected by the Principal Investigator. Images and loops of echo-exams were stored and made available for labs.

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Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-adjuvant and adjuvant systemic treatments (targeting specific molecular pathways), the high percentage of survival from breast cancer led CVD to become the first cause of death among survivors. Therefore, it is mandatory to adopt cardioprotective strategies to minimize CV side effects and CVD in general in breast cancer patients.

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Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults. Cardiac involvement is reported in 80% of cases and includes conduction disturbances, arrhythmias, subclinical diastolic and systolic dysfunction in the early stage of the disease; in contrast, severe ventricular systolic dysfunction occurs in the late stage of the disease. Echocardiography is recommended at the time of diagnosis with periodic revaluation in DM1 patients, regardless of the presence or absence of symptoms.

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