[The use of hemoperfusion through a suspension of cryopreserved hepatocytes in acute liver failure].

The present work deals with results of intensive therapy and temporary organ substitution by using hemoperfusion through a suspension of living donor hepatocytes in 71 patients with acute hepatic insufficiency. Hemoperfusion was performed through a suspension of fresh living hepatocytes or through a suspension of cryo-conserved (during 60 days) living hepatocytes. Lethality was 37-42%.

Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency.

The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electroencephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed.

[Evaluation of the functional activity of the liver following its heterotopic transplantation in experimental acute hepatic insufficiency].

The functional activity of the transplanted (additional) liver and its efficiency in the treatment of critical hepatic insufficiency was studied in experiments on dogs. Without an immunosuppression being used the additionally transplanted liver manifests its functional activity in the recipient's organism within 4 days and is able to support the animal's life for 3-4 days.

[Hemoperfusion through adsorbents as a method of preoperative preparation of patients with severe form of mechanical jaundice].

The method of haemoperfusion through the ion exchange resin and active carbon was used 15 times in 13 patients with heavy forms of mechanical subhepatogenous jaundice. The haemoperfusion was used as a method of preoperative preparation for reduction of hyperbilirubinemia and cholemic intoxication and for prevention of possible postoperative complications. One patient recovered.

[Surgical aspects of a temporary heterotopic transplantation of the liver].

The ways of settling some surgical aspects of a temporary heterotopic transplantation of the liver are analysed in the article. According to the obtained data the placement of the graft into the iliac zone of the abdominal cavity is the most convenient for a temporary heterotopic transplantation of an additional liver. An adequate vascularization of the additional organ can be effected via hepatic artery, which simplifies considerably the removal and replacement of this organ.

Intensive therapy for hepatic coma.

Of 45 patients observed in the ICU with severe acute hepatic insufficiency, 15 patients were in hepatic coma. All patients received combined treatment consisting of standard conservative methods (drug therapy) and surgical methods for temporary support of liver function (hemodialysis, exchange blood transfusion, pig liver perfusion). Intensive therapy which began during the early phase of hepatic coma enabled us to bring six patients out of the coma, four of whom completely recovered.

[Functional and biochemical parallels in two-stage devascularization of the liver].

Experiments were performed on mongrel dogs. Biochemical changes of the blood and functional disturbances in the organism were studied after a two-stage devascularization of the liver at different periods after the second stage, i.e.