Toxicological and pharmacological effects of Eugenia brasiliensis Lam. (Myrtaceae) leaves in mice.

Ethnopharmacological Relevance: Eugenia brasiliensis Lam., popularly known as "grumixama" or "Brazilian cherry", is widely used in folk medicine with astringent, diuretic, energizing, anti-rheumatic, and anti-inflammatory properties.

Aim Of The Study: Despite its traditional use, detailed toxicological studies of Eugenia brasiliensis are few.

Cytotoxicity and inflammation induced by Philodryas patagoniensis venom.

The Green racer Philodryas patagoniensis is a snake species from South America and accidents with this genus are often neglected. Therefore, this study aimed to evaluate the toxicological, cytotoxic, and inflammatory potential of P. patagoniensis venom (PpV).

Traditional uses, phytochemistry, and pharmacology of genus Vitex (Lamiaceae).

Vitex, the genus of the family Lamiaceae, comprises of about 230 species mostly distributed in the warm regions of Europe and temperate regions of Asia. Several Vitex species have been used as folk medicine in different countries for the treatment of various kinds of diseases and ailments. The main aim of this review is to collect and analyze the scientific information available about the Vitex species regarding their chemical constituents and pharmacological activities.

Sida tuberculata: In vitro cytotoxicity and in vivo anti-inflammatory effect.

Ethnopharmacological Relevance: Sida tuberculata R. E. Fries (Malvaceae) is a pioneer species considered a weed in farm fields in Southern Brazil.

Dry needling increases antioxidant activity and grip force in a rat model of muscle pain.

Background: Muscle pain syndromes (MPS) are one of the main causes of functional, structural and metabolic problems, being associated with tissue oxidative damage. Although dry needling is widely used in the treatment of MPS, there is little scientific evidence of its efficacy and underlying mechanisms of action.

Objectives: To investigate the effects of different dry needling techniques on thermal and mechanical hyperalgesia, locomotor and functional activity, and oxidative stress markers in a rat model of muscle pain.

effects of exposure to Golden trumpet in mice.

The Golden trumpet is a tree that presents beneficial health properties against various diseases. Thus, this study aims to verify the toxicity of bark extract, observing the effects of exposure to this extract in mice. For this, mice were separated in groups: saline (sterile solution .

Evaluation of monosodium iodoacetate dosage to induce knee osteoarthritis: Relation with oxidative stress and pain.

Aim: To determine the dose of monosodium iodoacetate (MIA) required to induce oxidative stress, as well as pain and edema; to confirm the induction of knee osteoarthritis (OA) symptoms in rats by the presence of reactive oxygen species (ROS) and reduction of antioxidant agents; and to verify the presence of histopathological injury in these affected joints.

Method: Biological markers of oxidative stress, pain, knee edema, and cartilage degeneration provided by different doses of MIA (0.5; 1.

Predictive antidiabetic activities of plants used by persons with Diabetes mellitus.

Background: There are several ways to identify medicinal power of phytoconstituents, such as in silico evaluations. Furthermore, ethnopharmacological researches are important alternatives for the identification of plants with medicinal potential. Significantly, medicinal plants are widely used by persons with Diabetes mellitus (DM) to treat manifestations of this syndrome.

In vitro and in silico antioxidant and toxicological activities of Achyrocline satureioides.

Ethnopharmacological Relevance: Achyrocline satureioides ("macela or marcela") is a medicinal plant, traditionally collected in "Good Friday" before sunrise. In traditional medicine, dried flowers of A. satureioides are used as anti-dyspeptic, antispasmodic and anti-inflammatory.

Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice.

This study was designed to evaluate the effects of Bauhinia forficata Link subsp. pruinosa (BF) tea on oxidative stress and liver damage in streptozotocin (STZ)-induced diabetic mice. Diabetic male mice have remained 30 days without any treatment.

The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations.

Ethnopharmacological Relevance: Bauhinia forficata (BF) has been traditionally used as tea in folk medicine of Brazil for treatment of Diabetes mellitus (DM).

Aim Of The Study: To evaluate the effects of BF leaf tea on markers of oxidative damage and antioxidant levels in an experimental model of hyperglycemia in human erythrocytes in vitro.

Materials And Methods: Human erythrocytes were incubated with high glucose concentrations or glucose and BF tea for 24h and 48h.

Cryotherapy reduces skeletal muscle damage after ischemia/reperfusion in rats.

The aim of this study was to analyze the effects of cryotherapy on the biochemical and morphological changes in ischemic and reperfused (I/R) gastrocnemius muscle of rats. Forty male Wistar rats were divided into control and I/R groups, and divided based on whether or not the rats were submitted to cryotherapy. Following the reperfusion period, biochemical and morphological analyses were performed.