Publications by authors named "Andreia S Machado"
Article Synopsis
- Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma, illustrated through a case involving a 60-year-old female with symptoms like fatigue, fever, weight loss, and swollen lymph nodes for six months.
- Despite extensive lab tests and imaging, the initial lymph node biopsy was inconclusive, but further PET-CT revealed a treatable adenopathy that confirmed the AITL diagnosis.
- The patient's condition worsened despite chemotherapy, leading to a focus on symptomatic treatment, ultimately resulting in her passing six months after diagnosis due to the challenges in identifying this complex disease.
Genetic and epigenetic alterations of microRNAs and implications for human cancers and other diseases.
Genes Chromosomes Cancer
March 2016
MicroRNAs (miRNAs) are a well-studied group of noncoding RNAs that control gene expression by interacting mainly with messenger RNA. It is known that miRNAs and their biogenesis regulatory machineries have crucial roles in multiple cell processes; thus, alterations in these genes often lead to disease, such as cancer. Disruption of these genes can occur through epigenetic and genetic alterations, resulting in aberrant expression of miRNAs and subsequently of their target genes.
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