Yellow fever virus investigation in tissues of vampire bats Desmodus rotundus during a wild yellow fever outbreak in Brazilian Atlantic Forest.

In the last decade a large outbreak of Yellow Fever (YF) has been observed in Brazilian Atlantic Forest region, traditionally a non-endemic area. In this scenario, the role of wild mammal species as YF reservoirs can be questioned, especially the hematophagous bat, Desmodus rotundus. So, the objective of this study was to analyze molecularly the presence of the YF virus (YFV) in hematophagous bats during a YF outbreak in Brazil.

COVID-19 and Brazilian Indigenous Populations.

The newly discovered SARS-CoV-2 is the cause of COVID-19, including severe respiratory symptoms with an important lethality rate and high dissemination capacity. Considering the indigenous people of Brazil, it is feared that COVID-19 will spread to these communities, causing another stage of decimation. Despite advances in indigenous health care in the country, there are still many challenges due to the social vulnerability of this population, whose lands continue to be illegally exploited.

Sofosbuvir use for yellow fever: a new perspective treatment.

Yellow fever is an acute febrile illness for which there is no specific antiviral treatment. Since 2016, Brazil has experienced two outbreaks, and collective health measures have been adopted to contain these grievances. However, published data about the drug sofosbuvir against flaviviruses are promising, suggesting the relevance of conducting future clinical trials.

[Prevalence of tuberculosis in incarcerated populations: systematic review and meta-analysisPrevalencia de tuberculosis en la población privada de libertad: revisión sistemática y metanálisis].

Objective: To estimate the prevalence of tuberculosis among incarcerated populations.

Method: A systematic review with meta-analysis was performed. The MEDLINE/PubMed, SciELO, and LILACS databases were searched for articles published from January 1997 to December 2016.

Meningococcal disease, a clinical and epidemiological review.

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa.

(Bio)Ethics and Primary Health Care: preliminary study on Family Clinics in the city of Rio de Janeiro, Brazil.

The Family Health Strategy (FHS) started out as the Family Health Program (FHP) in 1994, and has since has been re-thought and re-worked in Brazil as the primary rationale for reorganizing Primary Healthcare (PHC). Transforming the hegemonic PHC into FHS has resulted in many changes in how healthcare is provided, which have impacted different areas. For example, matters of (bio)ethics must still be elucidated.

NICeSim: an open-source simulator based on machine learning techniques to support medical research on prenatal and perinatal care decision making.

Objective: This paper describes NICeSim, an open-source simulator that uses machine learning (ML) techniques to aid health professionals to better understand the treatment and prognosis of premature newborns.

Methods: The application was developed and tested using data collected in a Brazilian hospital. The available data were used to feed an ML pipeline that was designed to create a simulator capable of predicting the outcome (death probability) for newborns admitted to neonatal intensive care units.

Plasmodium falciparum malaria: proteomic studies.

Despite advances in treatment and campaigns for prevention and control of malaria on the various continents where it is still rampant, this disease remains significantly relevant to the contemporary world. Plasmodium falciparum is the organism that is mainly responsible for severe malaria, which is characterized by disturbances in different organs and systems, with possibly fatal outcomes. Although incipient, proteomic studies of malaria have yielded favorable prospects for elucidating the biological aspects of Plasmodium as well as the pathophysiological, diagnostic, prophylactic, and therapeutic mechanisms of the disease.

CD4+CD25+ T lymphocytes and regulation of the immune system: perspectives for a pathophysiological understanding of sepsis.

The systemic inflammatory response represents the core pathogenic event of sepsis, underlying clinical manifestations and laboratory findings in patients. Numerous studies have shown that CD4+CD25+ T lymphocytes, also known as regulatory T lymphocytes (Treg), participate in the development of sepsis due to their ability to suppress the immune response. The present article discusses the role of Treg lymphocytes in sepsis based on a specific search strategy (Latin American and Caribbean Health Sciences / Literatura Latino-americana e do Caribe em Ciências da Saúde - LILACS, PubMed, and Scientific Electronic Library Online - SciELO) focusing on two main topics: the participation of Treg cells in inflammation and immunity as well as perspectives in the computational physiological investigation of sepsis.

Probable chronic renal failure caused by Lonomia caterpillar envenomation.

Erucism is a skin reaction to envenomation from certain poisonous caterpillar bristles. In Brazil, most reports of erucism provoked by Lonomia caterpillars are from the southern region. Most manifestations of erucism are local and include burning pain, itching, local hyperthermia and, rarely, blisters (benign symptoms with spontaneous regression in a few hours).

[Current debates on humanization and health: who are we?].

Bearing in mind that the Brazilian Unified Health System (SUS) is a social process in construction, and as health professionals are important individuals in this process, the role of permanent education as an important instrument to ensure humanized care is highlighted. The scope of this paper is to discuss the experience of the training course for health professionals of a public health outpatient unit, based on the prospect of humanized treatment, seeking the implementation of a sanitary model committed to the formal values contained in the SUS ideals. The teaching-learning methodology used is based on problem-solving, derived from the processing of a problem situation taken from the experience of teachers.

[Education and competences for the Brazilian Unified Health System (SUS): is it possible to find alternatives to the logic of late capitalism?].

The transformations that have revolutionized the labor market in contemporary society make it necessary to think of new alternatives for training health care professionals, thereby establishing a new approach to the health problems of individuals and collectives. Based on these considerations, this paper sets out to discuss training in health--based on the concept of competence--with a focus on education for the Brazilian Unified Health System (SUS), using attempts to analyze and propose an alternative to the system entrenched in the logic of late capitalism as a theoretical benchmark. It is thus a reflection on the subject, correlating theory and praxis, in constant and relentless movement of construction, deconstruction and (re)construction of propositions.

Proteomic updates on sepsis.

The increased knowledge regarding proteomic analysis techniques has allowed for better understanding of the molecular bases related to the identification of cell signaling, modifying protein, and post-translational modification pathways, in addition to the characterization of specific biological markers. Thus, documenting certain proteins expressed in sepsis is a promising approach to elucidate pathophysiological, diagnostic, therapeutic, and prognostic aspects in this condition with a purpose of applying them to clinical practice. Although the studies are still preliminary, proteomics may offer good benefits for the better management of septic patients.

Late-onset sepsis in preterm children in a neonatal intensive care unit: a three-year analysis.

Objective: To evaluate the prevalence factors and etiologies associated with late neonatal sepsis in preterm neonates in a neonatal intensive care unit.

Methods: This was a cross-sectional study of secondary data pertaining to preterm neonates admitted to the neonatal intensive care unit between 2008 and 2010 and was gathered from medical charts. The outcome variable, late neonatal sepsis, was characterized using the Brazilian national health surveillance agency criteria.

Nutritional therapy and neonatal sepsis.

This article reviews the current understanding of enteral and parenteral nutrition therapy in preterm infants, with an emphasis on very low birth weight babies. The protective effects of nutrition therapy against neonatal sepsis and necrotizing enterocolitis are discussed. Different methods of feeding preterm infants are evaluated.

Clostridium tetani infections in newborn infants: a tetanus neonatorum review.

Although tetanus is a preventable disease by vaccination, it continues to claim lives around the world. Whereas cases of accidental origin reflect insufficient population immunization, tetanus neonatorum reveals a double-nature fault-poor vaccination coverage of adults coupled with difficulties accessing appropriate prenatal care; this situation is aggravated by the extreme severity of tetanus in this age group in which the mortality rate can reach up to 80%. The early detection of tetanus in neonates is essential for immediately initiating the proper therapy.

Severe Plasmodium falciparum malaria.

Malaria is one of the world's leading parasitic diseases and affects a considerably large number of people. Considering the epidemiological reach of Plasmodium falciparum, which is almost always responsible for the most severe cases of malaria, a discussion of the clinical features and therapeutic interventions is important. In the cases of patients with severe malaria, admission to an intensive care unit is mandatory to reduce complications.

Sepsis: an update.

This paper aims to provide an update on the main aspects of sepsis, a very relevant health care issue. A number of hypotheses have been proposed to explain its origin, involving interactions between microorganisms and the innate immune system, inflammation/immune mediation and the coagulation system. The clinical features of sepsis are variable and depend on the primary site of infection.

[Chagas's disease and deep ecology: the anti-vectorial fight in question].

The inter-relations between man and the environment are among the main themes currently debated by the Brazilian public health. On such horizon, the questions concerning Chagas's disease are found to remain specially in the scope of the directed actions of control to the triatomine, the anti-vectorial fight , though already a century since its first description by Carlos Chagas, a major epidemiological problem in Latin America. Based on these considerations the present article will seek to discuss the main ecological aspects related to the American trypanosomiasis, emphasizing the control of the vectorial transmission in the context of the deep ecology.

[The influence of the social net of lactating mothers in the breastfeeding: the strategic role of the relatives and professionals of health].

The objective was to raise and classify scientific works on the influence of the social net of lactating mothers in the context of the breastfeeding. A bibliographical review was done in the main databases (MEDLINE, LILACS, SciELO), using as keywords: breastfeeding, weaning and family (and their versions in English and Spanish). Books, thesis, dissertations, and publications in international and national institutions were consulted (WHO, UNICEF, Ministry of Health).

[Bioethical analysis of the use of newly dead patients in medical learning].

Objective: The purpose of this article is to carry out, a discussion on the subject of bioethics and cadavers based upon a critic review of literature.

Methods: A review of literature, was made with a survey of articles between 1977 and 2007 in the sites 'Biblioteca Virtual de Saúde', PubMed and SciElo, utilizing the keywords: newly deceased patients, newly dead patients, simulators,. This was complemented by a critical evaluation of books published in the area of ethics and bioethics.

[Evaluation of the care to the pregnant woman's health in the context of the Family Health Program].

The importance of health systems and services evaluation has been evidenced in several discussions on policies for health and practices in services. Thus, this study was carried out to analyze the primary care to the pregnant women by the Family Health Program (PSF) in the municipality of Teixeiras, Minas Gerais State. According to the propositions by Donabedian (1990) who relates the dimensions of structure, process and result, a specific score system was used to analyze these dimensions and their respective attributes, classifying the program into the incipient, intermediate and advanced sceneries, if the following were obtained: from 0.