Effects of endogenous HS production inhibition on the homeostatic responses induced by acute high-salt diet consumption.

The gaseous modulator hydrogen sulfide (HS) is synthesized, among other routes, by the action of cystathionine-γ-lyase (CSE) and importantly participates in body fluid homeostasis. Therefore, the present study aimed to evaluate the participation of HS in behavioral, renal and neuroendocrine homeostatic responses triggered by the acute consumption of a high Na diet. After habituation, adult male Wistar rats were randomly distributed and maintained for seven days on a control [CD (0.