Publications by authors named "Andreia Florina Nita"
Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children.
J Pediatr Gastroenterol Nutr
December 2024
What Is Known: Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction.
What Is New: In children with achalasia, BoNT can be considered only in patients in whom rapid weight gain is important to improve surgical outcomes. BoNT has been suggested for treating cricopharyngeal achalasia and delayed gastric emptying.
Recent advances in the treatment of gastrointestinal motility disorders in children.
Expert Rev Gastroenterol Hepatol
December 2023
Introduction: Pediatric gastrointestinal motility disorders represent some of the most challenging clinical conditions with largely undefined pathogenetic pathways and therefore limited therapeutic options. Herein, we provide an overview of the recent advances in treatment options for these disorders and their clinical impact.
Areas Covered: PubMed and Medline databases were searched for relevant articles related to the treatment of achalasia, esophageal atresia, gastroparesis, PIPO and constipation published between 2017 and 2022.
Article Synopsis
- In pediatric patients with acute pancreatitis (AP), having a family history of pancreatic diseases is linked to an earlier onset of recurrent acute pancreatitis (ARP) and chronic pancreatitis (CP), particularly peaking in children aged 6-17 years.
- Analysis of data from the Hungarian Pancreatic Study Group showed that those with a positive family history had a significantly higher rate of ARP/CP and a greater tendency for idiopathic AP in early childhood, along with increased alcohol and smoking rates in adolescence and early adulthood.
- Contrary to beliefs about adults, positive family history does not predict ARP or CP in adults; therefore, it should not be treated as a prognostic factor for them
Aim: To evaluate how correct is made the diagnosis of autoimmune hepatitis (AIH) in children, comparing the adults scoring systems - the 1999 revised scoring system by International Autoimmune Hepatitis Group and the 2007 Simplified Scoring System. The inaccuracies in diagnosis have been analysed.
Methods: The two scoring systems have been applied for 28 children with AIH pre-treatment and 28 with Hepatitis B infection - matched by sex and age, all diagnosed between 2010 and 2017 in an emergency children's hospital in Bucharest, Romania.