Implementing a hash-based privacy-preserving record linkage tool in the OneFlorida clinical research network.

Objective: To implement an open-source tool that performs deterministic privacy-preserving record linkage (RL) in a real-world setting within a large research network.

Materials And Methods: We learned 2 efficient deterministic linkage rules using publicly available voter registration data. We then validated the 2 rules' performance with 2 manually curated gold-standard datasets linking electronic health records and claims data from 2 sources.

Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus.

Clinical trials are indispensable tools for evidence-based medicine. However, they are often criticized for poor generalizability. Traditional trial generalizability assessment can only be done after the trial results are published, which compares the enrolled patients with a convenience sample of real-world patients.

Colorectal cancer stages transcriptome analysis.

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths in the United States. The purpose of this study was to evaluate the gene expression differences in different stages of CRC. Gene expression data on 433 CRC patient samples were obtained from The Cancer Genome Atlas (TCGA).