Publications by authors named "Andrei Soritsa"
Purpose: To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes.
Methods: This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and sedentary behaviour were measured for 14 consecutive days using accelerometry as follows: (1) before IVF treatment, (2) during IVF at the implantation time, immediately after embryo transfer, and (3) after positive pregnancy test.
Article Synopsis
- Endometrial DNA methylation changes may contribute to endometriosis, but are influenced by the menstrual cycle, requiring careful analysis of hormonal cycles when studying related disorders.
- A study compared DNA methylation profiles from endometrial tissues of women with endometriosis and healthy controls across different menstrual phases, finding only 28 distinct methylation differences that were minimal overall.
- The findings highlight that menstrual cycle phases significantly affect epigenetic profiles, suggesting that any disease-specific methylation patterns must account for these normal cycle-related changes.
Objective: To determine whether circulating micro-RNA (miR) 200a, miR-200b, and miR-141 have altered levels in patients with endometriosis compared with control individuals.
Design: Experimental laboratory study.
Setting: University.
Accumulating data have shown the involvement of microRNAs (miRNAs) in endometriosis pathogenesis. In this study, we used a novel approach to determine the endometriotic lesion-specific miRNAs by high-throughput small RNA sequencing of paired samples of peritoneal endometriotic lesions and matched healthy surrounding tissues together with eutopic endometria of the same patients. We found five miRNAs specific to epithelial cells--miR-34c, miR-449a, miR-200a, miR-200b and miR-141 showing significantly higher expression in peritoneal endometriotic lesions compared to healthy peritoneal tissues.
View Article and Find Full Text PDFAim: To evaluate the effects of combined treatment approaches on endometriosis-associated infertility in different stages of endometriosis using laparoscopy, gonadotropin-releasing hormone (GnRH) agonist (GnRHa) therapy and in vitro fertilization (IVF).
Methods: This retrospective study was carried out on 179 women with surgically confirmed endometriosis. Patients were divided into subgroups: group 1 (stage I-II, n = 121) and group 2 (stage III-IV, n = 58).