Using in-line measurement and statistical analyses to predict tablet properties compressed using a Styl'One compaction simulator: A high shear wet granulation study.

High shear wet granulation (HSWG) is widely used in tablet manufacturing mainly because of its advantages in improving flowability, powder handling, process run time, size distribution, and preventing segregation. In-line process analytical technology measurements are essential in capturing detailed particle dynamics and presenting real-time data to uncover the complexity of the HSWG process and ultimately for process control. This study is to find relationships between Lenterra in-line measurements and granule properties and tablet properties.

Predicting tablet properties using In-Line measurements and evolutionary equation Discovery: A high shear wet granulation study.

High shear wet granulation (HSWG) is widely used in tablet manufacturing mainly because of its advantages in improving flowability, powder handling, process run time, size distribution, and preventing segregation. In line process analytical technology measurements are essential in capturing detailed particle dynamics and presenting real-time data to uncover the complexity of the HSWG process and ultimately for process control. This study presents an opportunity to predict the properties of the granules and tablets through torque measurement of the granulation bowl and the force exerted on a novel force probe within the powder bed.

Autonomous digitizer calibration of a Monte Carlo detector model through evolutionary simulation.

Simulating the response of a radiation detector is a modelling challenge due to the stochastic nature of radiation, often complex geometries, and multi-stage signal processing. While sophisticated tools for Monte Carlo simulation have been developed for radiation transport, emulating signal processing and data loss must be accomplished using a simplified model of the electronics called the digitizer. Due to a large number of free parameters, calibrating a digitizer quickly becomes an optimisation problem.