Publications by authors named "Andrei Mihai Stoian"
Int J Mol Sci
October 2024
Article Synopsis
- - mRNA vaccines for SARS-CoV-2 have shown great success, pushing interest in mRNA-based drugs due to their quick production and safety, but their instability and degradation in the body require better delivery systems.
- - Lipid nanoparticles (LNPs) are the best current option for safely delivering mRNA, but they need to be stored at low temperatures, which complicates distribution.
- - Lyophilization (freeze-drying) is a promising method to extend the shelf life of mRNA-LNPs under refrigeration, and recent studies indicate that optimizing this process can maintain the vaccines' effectiveness for over a year.
